Vascular Surgery, 126700Hospital Universitari Sagrat Cor & General de Catalunya, Barcelona, Spain.
Vascular Surgery, Clínica Vascular Barcelona, Barcelona, Spain.
Phlebology. 2020 Oct;35(9):724-733. doi: 10.1177/0268355520937615. Epub 2020 Jul 7.
To determine the quality of sclerosant foam produced with an automated preparation system with multiple combinations of sclerosing agents, gases, and device settings.
Single-use mixing capsules filled with air or O/CO and polidocanol (0.25, 1, or 3%) or sodium tetradecyl sulfate (0.2 or 1%) were coupled to a customized magnetic stirrer. Stirring speed and time were adjusted between 1500 and 4000 r/min and 30 and 60 s, respectively, and characteristics of the foam produced were measured: half-life, bubble diameter, and gas-to-liquid ratio.
With optimized device settings, the following foam characteristics were obtained: half-life range, 1.4 ± 0.9 to 5.2 ± 0.6 min; bubble diameter, 84 ± 14 to 119 ± 6 µm; and gas-to-liquid ratio, 5:1-7:1. Sodium tetradecyl sulfate foam was quicker to form than polidocanol but faster to degrade. Foams with low sclerosant concentrations and O/CO required higher speed and longer time.
Suitable foam characteristics could be obtained with all combinations of sclerosing agent, concentration, and gas.
确定使用具有多种硬化剂、气体和设备设置组合的自动化制备系统生产的硬化剂泡沫的质量。
将装有空气或 O/CO 和聚多卡醇（0.25%、1%或 3%）或十四烷基硫酸钠（0.2%或 1%）的一次性混合胶囊与定制的磁力搅拌器相连。搅拌速度和时间分别调整为 1500 至 4000 r/min 和 30 至 60 s，并测量产生的泡沫特性：半衰期、气泡直径和气液比。
通过优化设备设置，获得了以下泡沫特性：半衰期范围为 1.4±0.9 至 5.2±0.6 min；气泡直径为 84±14 至 119±6 µm；气液比为 5:1-7:1。十四烷基硫酸钠泡沫的形成速度快于聚多卡醇，但降解速度也更快。低浓度硬化剂和 O/CO 的泡沫需要更高的速度和更长的时间。
可以使用硬化剂、浓度和气体的所有组合获得合适的泡沫特性。
