来自白色念珠菌多烯抗生素抗性突变体的羊毛甾醇、酵母甾醇、麦角甾醇和钝叶醇。
Eburicol, lichesterol, ergosterol, and obtusifoliol from polyene antibiotic-resistant mutants of Candida albicans.
作者信息
Subden R E, Safe L, Morris D C, Brown R G, Safe S
出版信息
Can J Microbiol. 1977 Jun;23(6):751-4. doi: 10.1139/m77-111.
DOI:10.1139/m77-111
PMID:326362
Abstract
Two classes of polyene-resistant mutants were isolated from survivors of N-methyl-N'-nitro-N-nitrosoguanidine treatment of a wild-type Candida albicans. An analysis of the major sterols of one class revealed an accumulation of lichesterol and fecosterol while the other class accumulated eburicol, obtusifoliol, and lanosterol with minor quantities of C28 sterols.
摘要
从经N-甲基-N'-硝基-N-亚硝基胍处理的野生型白色念珠菌的存活菌株中分离出两类对多烯耐药的突变体。对其中一类突变体的主要甾醇进行分析发现，其积累了地衣甾醇和粪甾醇，而另一类则积累了羊毛甾醇、钝叶醇和羊毛甾醇，并伴有少量C28甾醇。
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