Hernández Rosendo G, De Zeeuw Chris I, Zhang Ruyan, Yakusheva Tatyana A, Blazquez Pablo M
Department of Otolaryngology, Washington University, St. Louis, MO 63110.
Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands.
Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17348-17358. doi: 10.1073/pnas.2002177117. Epub 2020 Jul 7.
The cerebellar posterior vermis generates an estimation of our motion (translation) and orientation (tilt) in space using cues originating from semicircular canals and otolith organs. Theoretical work has laid out the basic computations necessary for this signal transformation, but details on the cellular loci and mechanisms responsible are lacking. Using a multicomponent modeling approach, we show that canal and otolith information are spatially and temporally matched in mouse posterior vermis Purkinje cells and that Purkinje cell responses combine translation and tilt information. Purkinje cell-specific inhibition of protein kinase C decreased and phase-shifted the translation component of Purkinje cell responses, but did not affect the tilt component. Our findings suggest that translation and tilt signals reach Purkinje cells via separate information pathways and that protein kinase C-dependent mechanisms regulate translation information processing in cerebellar cortex output neurons.
小脑后蚓部利用来自半规管和耳石器官的线索，生成我们在空间中的运动（平移）和方向（倾斜）估计。理论研究已经阐述了这种信号转换所需的基本计算，但负责的细胞位点和机制的细节尚不清楚。使用多组分建模方法，我们表明在小鼠后蚓部浦肯野细胞中，半规管和耳石信息在空间和时间上是匹配的，并且浦肯野细胞反应结合了平移和倾斜信息。对蛋白激酶C的浦肯野细胞特异性抑制降低了浦肯野细胞反应的平移成分并使其相位偏移，但不影响倾斜成分。我们的研究结果表明，平移和倾斜信号通过独立的信息通路到达浦肯野细胞，并且蛋白激酶C依赖性机制调节小脑皮质输出神经元中的平移信息处理。
