Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
BMJ Open. 2020 Jul 6;10(7):e037478. doi: 10.1136/bmjopen-2020-037478.
Coeliac disease (CD) is a genetic autoimmune disorder characterised by a permanent sensitivity to the gluten contained in some grains. Certain patient groups are considered high risk for the development of CD, including, but not limited to, those with chromosomal disorders such as Turner syndrome (TS). Here, we present a protocol for a systematic review and meta-analysis that aims to comprehensively summarise the literature, and quantitatively estimate the weighted strength of the association between TS and CD.
Our protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 guidelines. We will search PubMed, Scopus, Web of Science and Embase databases for relevant articles. Variant and broad search terms will be selected for identifying epidemiological studies reporting on the crude and/or adjusted association between TS and CD. Retrieved citations will be screened, and data from the eligible research reports against specific eligibility criteria will be extracted. We will then assess the risk of bias associated with the eligible studies using the Newcastle-Ottawa Scale. The overall weighted strength of the pooled association will be quantified using the random-effects model.
This review will use data from published literature; hence, ethical approval will not be needed. The resulting review will be the first to produce a comprehensive synthesis of the strength of the association between TS and CD. The results will be disseminated through a peer-reviewed journal as well as in local and international conferences and symposiums. Results dissemination would help healthcare providers and policy-makers to make informed decisions regarding the diagnosis and management of CD in high-risk individuals.
CRD42019131881, dated 3 September 2019.
乳糜泻（CD）是一种遗传性自身免疫性疾病，其特征是对某些谷物中含有的麸质永久敏感。某些患者群体被认为是 CD 发展的高危人群，包括但不限于特纳综合征（TS）等染色体紊乱患者。在这里，我们提出了一项系统评价和荟萃分析的方案，旨在全面总结文献，并定量估计 TS 与 CD 之间关联的加权强度。
我们的方案遵循 2015 年系统评价和荟萃分析报告的首选报告项目。我们将在 PubMed、Scopus、Web of Science 和 Embase 数据库中搜索相关文章。将选择变体和广泛的搜索词来确定报告 TS 和 CD 之间粗关联和/或调整关联的流行病学研究。筛选检索到的引用，并根据具体的纳入标准从合格的研究报告中提取数据。然后，我们将使用纽卡斯尔-渥太华量表评估合格研究的偏倚风险。使用随机效应模型量化汇总关联的整体加权强度。
本综述将使用已发表文献中的数据；因此，不需要伦理批准。该综述将首次全面综合 TS 和 CD 之间关联的强度。结果将通过同行评议的期刊以及当地和国际会议和研讨会进行传播。结果传播将有助于医疗保健提供者和政策制定者在高风险个体中做出关于 CD 的诊断和管理的明智决策。
PROSPERO 注册号：CRD42019131881，日期为 2019 年 9 月 3 日。
