Department of Preventive Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang, China.
Department of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, China.
BMJ Open. 2021 Aug 18;11(8):e048451. doi: 10.1136/bmjopen-2020-048451.
The thyroid cancer incidence has been increasing all over the world. However, the aetiology of thyroid cancer remains unclear. A growing body of evidence suggested exposure to persistent organic pollutants (POPs) may play a role in the initiation of thyroid cancer, but the results are generally inconsistent across studies. This review aims to synthesise the evidence for the health effects of POPs on the risk of thyroid cancer.
This protocol was reported in accordance to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA) statements. A comprehensive search, including electronic database search (eg, PubMed, Embase, ProQuest and CNKI), website search and manual search, will be performed to identify all eligible studies. The Population, Exposure, Comparator and Outcome framework was used to clarify the inclusion and exclusion criteria. The Newcastle-Ottawa Scale will be used to assess the quality of included studies. Maximally adjusted effect estimates from individual studies will be summarised with random-effect models in a conservative manner. statistics and Q-tests will be used to test the heterogeneity across studies. We will perform extensive sensitivity analyses, such as confounding risk ratio (confounding), E-value, fixed-effect models, excluding the most relatively weighted study, including only the high-quality studies and many predesigned subgroup analyses, etc. The findings will be reported in accordance to the PRISMA guidelines.
Ethical approval is not required in this systematic review of published literatures. The results will be published in a peer-reviewed journal and presented at relevant conferences.
CRD42020181343.
全球范围内甲状腺癌的发病率一直在上升。然而，甲状腺癌的病因仍不清楚。越来越多的证据表明，接触持久性有机污染物（POPs）可能在甲状腺癌的发生中起作用，但研究结果普遍不一致。本综述旨在综合持久性有机污染物对甲状腺癌风险的健康影响证据。
本方案按照系统评价和荟萃分析报告的首选报告项目（PRISMA）声明进行报告。将进行全面搜索，包括电子数据库搜索（例如，PubMed、Embase、ProQuest 和 CNKI）、网站搜索和手动搜索，以确定所有合格的研究。使用人口、暴露、对照和结局框架来阐明纳入和排除标准。将使用纽卡斯尔-渥太华量表来评估纳入研究的质量。将以保守的方式使用随机效应模型总结来自个体研究的最大调整效应估计值。将使用统计和 Q 检验来检验研究之间的异质性。我们将进行广泛的敏感性分析，例如混杂风险比（混杂）、E 值、固定效应模型、排除最具权重的研究、仅包括高质量研究以及许多预设的亚组分析等。将按照 PRISMA 指南报告研究结果。
本发表文献的系统评价不需要伦理批准。研究结果将发表在同行评议的期刊上，并在相关会议上展示。
PROSPERO 注册号：CRD42020181343。
