Dashtelei Ali Akbar, Nitsche Michael A, Bakhtiari Jalal, Habibi Seyed Amirhassan, Sepandi Mojtaba, Khatoonabadi Ahmad Reza
Speech Therapy Department, Tehran University of Medical Sciences, Tehran, Iran.
Department Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.
EXCLI J. 2020 Jun 4;19:745-749. doi: 10.17179/excli2020-1453. eCollection 2020.
Parkinson's disease (PD) is a neurodegenerative disease of the central nervous system that is characterized by a set of motor and non-motor symptoms. Impaired swallowing or dysphagia is one relatively common motor symptom in patients with PD. We investigated whether neuroplasticity induction by spaced transcranial Direct Current Stimulation (tDCS) combined with conventional swallowing therapy leads to long-lasting effects on swallowing ability in patients with PD. We present a case of a 61-year-old male PD patient with dysphagia. Conventional Swallowing Therapy (CDT) combined with tDCS (bilateral anodal, 1 mA, 20 min, 10 online sessions, twice daily with a 20 min interval in between for five days over two weeks) was applied over the pharyngeal motor cortex. Our findings suggest that anodal tDCS combined with CDT is feasible, safe, and well-tolerated, and leads to a clinically relevant improvement of swallowing functions.
帕金森病（PD）是一种中枢神经系统的神经退行性疾病，其特征是一系列运动和非运动症状。吞咽障碍或吞咽困难是帕金森病患者相对常见的一种运动症状。我们研究了间隔经颅直流电刺激（tDCS）联合传统吞咽疗法诱导的神经可塑性是否会对帕金森病患者的吞咽能力产生持久影响。我们报告了一例61岁男性帕金森病吞咽困难患者的病例。在咽运动皮层应用传统吞咽疗法（CDT）联合tDCS（双侧阳极，1 mA，20分钟，10次在线治疗，每天两次，间隔20分钟，两周内连续五天）。我们的研究结果表明，阳极tDCS联合CDT是可行、安全且耐受性良好的，并能在临床上显著改善吞咽功能。
