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Outer membrane permeability and beta-lactamase content in Pseudomonas maltophilia clinical isolates and laboratory mutants.

作者信息

Mett H, Rosta S, Schacher B, Frei R

机构信息

Pharmaceuticals Division, CIBA-GEIGY Limited, Basel, Switzerland.

出版信息

Rev Infect Dis. 1988 Jul-Aug;10(4):765-9. doi: 10.1093/clinids/10.4.765.

DOI:10.1093/clinids/10.4.765
PMID:3263685
Abstract

Low outer-membrane permeability appears to be responsible for the generally high degree of antibiotic resistance of Pseudomonas maltophilia. Constitutive overproduction of beta-lactamases affects the sensitivity of these bacteria only to those beta-lactam antibiotics that are hydrolyzed by strain-specific beta-lactamases and that do not efficiently induce these enzymes in inducible strains.

摘要

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