Kempegowda Punith, Melson Eka, Manolopoulos Konstantinos N, Arlt Wiebke, O'Reilly Michael W
Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK.
RCSI Medical School, Beaumont Hospital, Dublin, 2, Ireland.
Ther Adv Endocrinol Metab. 2020 Jun 24;11:2042018820934319. doi: 10.1177/2042018820934319. eCollection 2020.
Polycystic ovary syndrome (PCOS) has been traditionally perceived as a reproductive disorder due to its most common presentation with menstrual dysfunction and infertility. However, it is now clear that women with PCOS are at increased risk of metabolic dysfunction, from impaired glucose tolerance and type 2 diabetes mellitus to nonalcoholic fatty liver disease and cardiovascular disease. PCOS is characterised by androgen excess, with cross-sectional data showing that hyperandrogenism is directly complicit in the development of metabolic complications. Recent studies have also shown that C11-oxy androgens are emerging to be clinically and biochemically significant in PCOS, thus emphasising the importance of understanding the impact of both classic and C11-oxy androgens on women's health. Here we discuss androgen metabolism in the context of PCOS, and dissect the role played by androgens in the development of metabolic disease through their effects on metabolic target tissues in women.
多囊卵巢综合征（PCOS）传统上被视为一种生殖系统疾病，因为其最常见的表现是月经功能紊乱和不孕。然而，现在很清楚的是，患有PCOS的女性出现代谢功能障碍的风险增加，从糖耐量受损和2型糖尿病到非酒精性脂肪性肝病和心血管疾病。PCOS的特征是雄激素过多，横断面数据表明高雄激素血症直接参与了代谢并发症的发生。最近的研究还表明，C11-氧代雄激素在PCOS中在临床和生化方面正变得越来越重要，从而强调了了解经典雄激素和C11-氧代雄激素对女性健康影响的重要性。在此，我们在PCOS的背景下讨论雄激素代谢，并通过雄激素对女性代谢靶组织的影响来剖析雄激素在代谢性疾病发生中所起的作用。
