Yang Yanting, Liu Lin, Hu Ning, Huo Huyan, Yang Xin, Wang Fang
Department of Obstetrics and Gynecology, Second Clinical Medical College, Lanzhou University, Lanzhou, China.
Department of Reproductive Medicine, Second Clinical Medical College, Lanzhou University, Lanzhou, China.
Front Glob Womens Health. 2025 Mar 3;6:1520641. doi: 10.3389/fgwh.2025.1520641. eCollection 2025.
Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders among women of reproductive age, often accompanied by a series of symptoms such as hirsutism, hair loss, menstrual disorders and obesity, resulting in an increasing risk of depression and anxiety in such patients.
A total of 413 patients in the Reproductive Medicine Center of the Second Hospital of Lanzhou University from June 2021 to June 2023 were enrolled. We collected sociodemographic information and lifestyle-related factors using a structured questionnaire. Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Scale (GAD-7) were used to evaluate the psychological status of the subjects. Sleep-related variables were assessed using the Pittsburgh Sleep Quality Index (PSQI), and metabolic measures were collected from patients' medical records.
Compared with the control group, PCOS patients were younger, the average age was (27.39 ± 3.48) years old, and the BMI value was higher, the difference was statistically significant ( < 0.05). The proportions of depression and anxiety in PCOS patients were 47.7% and 39.9%, respectively. In PCOS patients with depressive anxiety symptoms, the proportions of mild, moderate, moderately severe and severe depression were 31.6%, 12.4%, 1.6% and 2.1%, respectively. The proportions of mild, moderate, moderately severe and severe anxiety were 30.6%, 6.2%, 1.0% and 2.1%, respectively. Depression was significantly associated with serum free triiodothyronine (FT3) OR (95% CI) = 3.33 (1.30-8.55), sleep duration 4.99 (1.45-17.23) and daytime dysfunction 8.24 (3.53-19.22). Anxiety was significantly associated with daytime dysfunction OR (95% CI) = 3.45 (1.78-6.70). No association was found between mental health and other metabolic characteristics in PCOS patients ( > 0.05).
According to the results of the current study, a high proportion of women with PCOS have mental health disorders, and there is a significant correlation between mental health disorders and sleep conditions.
多囊卵巢综合征（PCOS）是育龄女性中最常见的生殖内分泌疾病之一，常伴有多毛、脱发、月经紊乱和肥胖等一系列症状，导致此类患者患抑郁症和焦虑症的风险增加。
选取2021年6月至2023年6月在兰州大学第二医院生殖医学中心就诊的413例患者。我们使用结构化问卷收集社会人口学信息和生活方式相关因素。采用患者健康问卷（PHQ - 9）和广泛性焦虑障碍量表（GAD - 7）评估研究对象的心理状态。使用匹兹堡睡眠质量指数（PSQI）评估睡眠相关变量，并从患者病历中收集代谢指标。
与对照组相比，PCOS患者年龄更小，平均年龄为（27.39 ± 3.48）岁，且BMI值更高，差异有统计学意义（< 0.05）。PCOS患者中抑郁症和焦虑症的比例分别为47.7%和39.9%。在有抑郁焦虑症状的PCOS患者中，轻度、中度、中重度和重度抑郁症的比例分别为31.6%、12.4%、1.6%和2.1%。轻度、中度、中重度和重度焦虑症的比例分别为30.6%、6.2%、1.0%和2.1%。抑郁症与血清游离三碘甲状腺原氨酸（FT3）OR（95%CI）= 3.33（1.30 - 8.55）、睡眠时间4.99（1.45 - 17.23）和日间功能障碍8.24（3.53 - 19.22）显著相关。焦虑症与日间功能障碍OR（95%CI）= 3.45（1.78 - 6.70）显著相关。未发现PCOS患者心理健康与其他代谢特征之间存在关联（> 0.05）。
根据本研究结果，高比例的PCOS女性存在心理健康障碍，且心理健康障碍与睡眠状况之间存在显著相关性。
