Guttman M, Yong V W, Kim S U, Calne D B, Martin W R, Adam M J, Ruth T J
Department of Medicine, University of British Columbia, Canada.
Synapse. 1988;2(5):469-73. doi: 10.1002/syn.890020502.
In cynomolgus monkeys, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces irreversible clinical, chemical, and pathological alterations that are similar to those found in Parkinson's disease. Unilateral carotid injections of this toxin produce ipsilateral nigrostriatal dopamine depletion while sparing the contralateral dopaminergic pathways. In order to study the damage to the nigrostriatal dopamine system in asymptomatic animals after unilateral MPTP administration, positron emission tomography (PET) scans were performed with [18F]fluoro-L-dopa (6-FD). This study demonstrates that clinically asymptomatic MPTP lesions may be assessed in vivo using 6-FD and PET.
在食蟹猴中，1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）会产生不可逆的临床、化学和病理改变，这些改变与帕金森病中发现的改变相似。单侧颈动脉注射这种毒素会导致同侧黑质纹状体多巴胺耗竭，而对侧多巴胺能通路则不受影响。为了研究单侧给予MPTP后无症状动物黑质纹状体多巴胺系统的损伤情况，使用[18F]氟-L-多巴（6-FD）进行了正电子发射断层扫描（PET）。这项研究表明，临床上无症状的MPTP损伤可以使用6-FD和PET在体内进行评估。
