Enache Irina, IoniȚĂ Elena, Mitroi Mihaela, Anghelina Florin, MogoantĂ Carmen, Ciolofan Sorin, CĂpitĂnescu Alina, Stepan Alex, Simionescu Cristiana
PhD student, Department of ENT, University of Medicine and Pharmacy of Craiova, Romania.
Department of ENT, University of Medicine and Pharmacy of Craiova, Romania.
Curr Health Sci J. 2020 Jan-Mar;46(1):66-71. doi: 10.12865/CHSJ.46.01.09. Epub 2020 Mar 31.
Chronic rhinosinusitis with nasal polyps of allergic etiology is one of the most common pathology in the ENT sphere that affect a significant percentage of population. The paper aims to establish the involvement of the allergic component in the genesis of nasal polyposis. The study included 150 nasal polyps from patients hospitalized and operated in the ENT Department of Craiova's Clinical Emergency County Hospital. The biological material was fixed in 10% buffered formalin, processed by classical paraffin embedding technique followed by hematoxylin-eosin staining and it was interpreted in the Pathology Department of the same hospital. We evaluated a number of histopathological parameters that were given severity scores. The most common changes at epithelial level were: basal layer hyperplasia observed in 87 cases (58%), goblet cell hyperplasia in 121 cases (80.66%), basal membrane thickening with values between 10-42μm corresponding to a number of 118 cases (78.66%). The most important stromal changes were edema in 88% and infiltration with eosinophils 100%, indicating the allergic nature of this disease.
变应性病因引起的慢性鼻-鼻窦炎伴鼻息肉是耳鼻喉领域最常见的病理状况之一，影响着相当大比例的人群。本文旨在确定变应性成分在鼻息肉形成过程中的作用。该研究纳入了150例来自克拉约瓦市临床急救县医院耳鼻喉科住院并接受手术的患者的鼻息肉。生物材料用10%缓冲福尔马林固定，采用经典石蜡包埋技术处理，随后进行苏木精-伊红染色，并在同一家医院的病理科进行解读。我们评估了一些组织病理学参数并给出严重程度评分。上皮层面最常见的变化为：87例（58%）观察到基底层增生，121例（80.66%）杯状细胞增生，118例（78.66%）基膜增厚，厚度在10 - 42μm之间。最重要的间质变化为88%出现水肿，100%有嗜酸性粒细胞浸润，表明该疾病的变应性本质。
