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关于苯暴露对遗传损伤、血液毒性、端粒长度以及代谢和DNA修复基因多态性影响的数据集。

Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes.

作者信息

Ren Jing-Chao, Liu Huan, Zhang Guang-Hui, Wang Tongshuai, Li Jingzhi, Dong Tingting, Wu Hantian, Xia Zhao-Lin

机构信息

School of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, China.

Department of Occupational Health and Toxicology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China.

出版信息

Data Brief. 2020 Jun 18;31:105869. doi: 10.1016/j.dib.2020.105869. eCollection 2020 Aug.

Abstract

In this paper, we present an occupational dataset to evaluate benzene exposure on the effective biomarkers of genetic damage, indicated as cytokinesis-block micronucleus (MN) frequency, hematotoxicity, indicated as white blood cells (WBC) counts, and molecular marker of telomere length (TL). And we further to eliminate the mechanism of benzene induced damage. Then evaluate the effects of sites polymorphism in environmental response genes, including 18 sites in metabolic and DNA repair genes, and the interaction between gene polymorphism and benzene exposure. This dataset is supplementary to the submitted research by [1] focused on the biomarkers TL, and a detailed description of the subjects sampling, biomarkers detection, data analysis and discussion are discussed in detail.

摘要

在本文中,我们展示了一个职业数据集,以评估苯暴露对遗传损伤有效生物标志物(以胞质分裂阻滞微核(MN)频率表示)、血液毒性(以白细胞(WBC)计数表示)以及端粒长度(TL)分子标志物的影响。并且我们进一步探究苯诱导损伤的机制。然后评估环境反应基因中位点多态性的影响,包括代谢和DNA修复基因中的18个位点,以及基因多态性与苯暴露之间的相互作用。该数据集是对[1]提交的关于生物标志物TL研究的补充,详细讨论了受试者采样、生物标志物检测、数据分析和讨论的详细情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6347/7327812/64fadd020a39/gr1.jpg

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