Liu Yuxiao, Wang Yuetong, Wang Yu, Shu Yilai, Tan Hui, Zhao Yuanjin
Department of Neurosurgery, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China.
ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institute of Biomedical Sciences, Fudan University, Shanghai, 200031, China.
Bioact Mater. 2020 Jun 30;5(4):917-923. doi: 10.1016/j.bioactmat.2020.06.013. eCollection 2020 Dec.
Because of the unique features of spherical symmetry, angle-independency, good monodispersity, controllable components and morphologies, structural color particles (SCPs) have found great significances in various fields such as sensing, monitoring, biological assays, etc. Here, inspired by the melanosome-derived bright structural colors and the self-adhesivity of mussels, we present a kind of bioinspired SCPs assembled from polydopamine (PDA)-adhered multi-layer graphene oxide (GO) encapsulated silica nanoparticles (SNs). It is demonstrated that compared with traditional SCPs, the designed particles possess brighter and more vibrant structural colors, and no complicated modification is required during the functionalization process due to the abundant inherent functional groups of GO. The resultant SCPs are verified to be capable for direct hybridization chain reaction and multiplexed nucleic acid assays. These properties indicate the promising prospects of our designed SCPs.
由于具有球对称性、角度无关性、良好的单分散性、可控的成分和形态等独特特性,结构色颗粒(SCPs)在传感、监测、生物分析等各个领域都具有重要意义。在此,受黑素体衍生的明亮结构色和贻贝的自粘性启发,我们展示了一种由聚多巴胺(PDA)粘附的多层氧化石墨烯(GO)包裹的二氧化硅纳米颗粒(SNs)组装而成的仿生SCPs。结果表明,与传统SCPs相比,所设计的颗粒具有更明亮、更鲜艳的结构色,并且由于GO丰富的固有官能团,在功能化过程中无需复杂的修饰。所得的SCPs被证实能够用于直接杂交链式反应和多重核酸分析。这些特性表明我们所设计的SCPs具有广阔的应用前景。