Centre for international Health, Otago Medical School, University of Otago, Dunedin, New Zealand.
Department of Pathology and Molecular Medicine, University of Otago, Wellington, New Zealand.
J Infect Dis. 2021 Feb 24;223(4):719-720. doi: 10.1093/infdis/jiaa411.
In Indonesia, BCG vaccine protection against Mycobacterium tuberculosis infection decreased with increasing exposure to the pathogen. We aimed to validate these findings in Africa. Poisson regression was used to estimate BCG protection, stratified by pathogen exposure using an exposure score, against enzyme-linked immunospot assay conversion at 3 months in 220 Gambian case contacts. Although the interaction between BCG and exposure was not significant (P = .13), BCG protection was strongest in the lowest-exposure tertile (relative risk, 0.35 [95% confidence interval, .15-.82; P = .02] vs 0.50 [.30-.83; P = .008] and 0.71 (.45-1.13; P = .1] for the middle and highest-exposure tertiles, respectively. These results are consistent with those from Indonesia.
在印度尼西亚，BCG 疫苗对结核分枝杆菌感染的保护作用随着病原体接触的增加而降低。我们旨在验证这些发现是否也适用于非洲。我们采用泊松回归分析，使用暴露评分来分层分析病原体暴露，对 220 名冈比亚病例接触者在 3 个月时酶联免疫斑点测定转化进行分析，以评估 BCG 对其的保护作用。虽然 BCG 与暴露之间的相互作用不显著（P =.13），但 BCG 的保护作用在最低暴露三分位组最强（相对风险，0.35 [95%置信区间，0.15-0.82；P =.02]，而中三分位组和最高三分位组的相对风险分别为 0.50 [0.30-0.83；P =.008]和 0.71 [0.45-1.13；P =.1]）。这些结果与印度尼西亚的结果一致。
