Lehrstuhl für Organische Chemie I, Bioorganische Chemie, Ruhr-Universität Bochum, 44780, Bochum, Germany.
Chemistry. 2020 Jul 22;26(41):9032-9035. doi: 10.1002/chem.201905594. Epub 2020 Jul 8.
We re-evaluate our claim of a high diastereoselectivity in the self-relicating Diels-Alder reaction between maleimide 1 and fulvene 3. It was shown that the system has a diastereoselectivity of 1.8:1 for NN-4:NX-4, which is contrary to the 16:1 ratio claimed by Dieckmann et al. The analysis of H NMR monitoring of the reaction revealed that both replicators show sigmoidal growth which is typical for auto-catalytic systems.
我们重新评估了我们在马来酰亚胺 1 和富烯 3 之间的自复制 Diels-Alder 反应中高非对映选择性的说法。结果表明，该体系对 NN-4:NX-4 的非对映选择性为 1.8:1，与 Dieckmann 等人声称的 16:1 比例相反。对反应的 H NMR 监测分析表明，两种复制子都表现出典型的自催化体系的 S 形增长。
