Chen P P, Liu M F, Sinha S, Carson D A
Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037.
Arthritis Rheum. 1988 Nov;31(11):1429-31. doi: 10.1002/art.1780311113.
Recently, the heavy chain of 16/6 idiotype-positive human anti-DNA antibodies was found to be similar, but not identical, to the VH26 gene. We resequenced the VH26 gene and found that its coding sequence is actually identical to the complementary DNA sequence of the anti-DNA antibodies previously described. Together with the previous data, our findings demonstrate that some human autoantibodies are encoded directly by immunoglobulin V region genes, and that these V region genes are remarkably conserved in populations.
最近，发现16/6独特型阳性人抗DNA抗体的重链与VH26基因相似，但并不完全相同。我们对VH26基因进行了重新测序，发现其编码序列实际上与先前描述的抗DNA抗体的互补DNA序列相同。结合先前的数据，我们的研究结果表明，一些人类自身抗体直接由免疫球蛋白V区基因编码，并且这些V区基因在人群中显著保守。
