Schroeder H W, Ippolito G C, Shiokawa S
Department of Medicine, University of Alabama, Birmingham 35294-3300, USA.
Vaccine. 1998 Aug-Sep;16(14-15):1383-90. doi: 10.1016/s0264-410x(98)00096-6.
In man, as in mouse, diversification of the antibody repertoire appears to follow a strict developmental program whereby antigen specificities are serially acquired during ontogeny. When compared to the adult repertoire, the fetal antibody repertoire is highly enriched for polyreactive specificities of low affinity. Although the mechanisms governing the development of this fetal repertoire differ between human and mouse, the composition and structure of the fetal antibodies produced by both species are quite homologous. Specifically, both species use similar V gene segments and restrict the sequence and structure of the third complementarity determining region (HCDR3) of the antibody heavy chain. The precise role that this restriction of the HCDR3 might play in the development of immunocompetence in the human remains to be elucidated.
与小鼠一样，人类抗体库的多样化似乎遵循严格的发育程序，据此在个体发育过程中依次获得抗原特异性。与成人抗体库相比，胎儿抗体库高度富集低亲和力的多反应性特异性。尽管人类和小鼠中控制这种胎儿抗体库发育的机制不同，但两个物种产生的胎儿抗体的组成和结构相当同源。具体而言，两个物种都使用相似的V基因片段，并限制抗体重链的第三个互补决定区（HCDR3）的序列和结构。HCDR3的这种限制在人类免疫能力发育中可能发挥的确切作用仍有待阐明。
