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酒精使用障碍不利于肋骨骨折愈合:19638 例肋骨骨折患者的全国性分析。

Alcohol Use Disorder Is Bad for Broken Ribs: A Nationwide Analysis of 19,638 Patients With Rib Fractures.

机构信息

Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona.

Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona.

出版信息

J Surg Res. 2020 Nov;255:556-564. doi: 10.1016/j.jss.2020.05.053. Epub 2020 Jul 5.

Abstract

BACKGROUND

Alcohol use disorder (AUD) has deleterious effects on many organ systems. The aim of our study was to assess the impact of AUD on outcomes in patients with rib fractures. We hypothesized that AUD is associated with increased risk adverse outcomes.

METHODS

We performed a 2013-2014 retrospective analysis of all adult trauma patients diagnosed with rib fractures from the American College of Surgeons-Trauma Quality Improvement Program database. We excluded patients who were acutely intoxicated with alcohol. Patients were stratified into two groups: AUD + and AUD -. A 1:1 ratio propensity score matching for demographics, admission vitals, injury severity, smoking status, operative intervention, and number of rib fractures was performed. Outcome measures were in-hospital complications, mortality, hospital and intensive care unit length of stay, and ventilator days.

RESULTS

We matched 19,638 patients (AUD +:9,819, AUD -:9819). Mean age was 53 ± 22y, and median injury severity score was 15[10-20]. Matched groups were similar in age (P = 0.18), smoking status (P = 0.82), injury severity score (P = 0.28), chest Abbreviated Injury Scale (P = 0.24), and number of rib fractures (2[1-4] versus 2[1-4], P = 0.86). Alcoholic patients had higher rates of pneumonia (18.1% versus 9.2%, P < 0.01), unplanned intubation (18.5% versus 9.7, P < 0.001), sepsis (10.8% versus 6.3%, P < 0.001), acute respiratory distress syndrome (12.2% versus 7.4%, P < 0.001), and mortality (8.0 versus 5.7%, P < 0.001). Patients with AUD spent more days in the hospital and intensive care unit . There was no difference in ventilator days between the two groups.

CONCLUSIONS

Patients with AUD and rib fractures had higher rates of adverse events than patients without AUD. Early identification of patients with rib fractures with AUD may allow better resource allocation and help improve outcomes.

LEVEL OF EVIDENCE

Level III prognostic.

摘要

背景

酒精使用障碍(AUD)对许多器官系统都有有害影响。我们研究的目的是评估 AUD 对肋骨骨折患者结局的影响。我们假设 AUD 与不良结局风险增加相关。

方法

我们对美国外科医师学会创伤质量改进计划数据库中所有诊断为肋骨骨折的成年创伤患者进行了 2013-2014 年的回顾性分析。我们排除了急性酒精中毒的患者。患者分为 AUD+ 和 AUD-两组。采用倾向评分 1:1 匹配进行人口统计学、入院生命体征、损伤严重程度、吸烟状况、手术干预和肋骨骨折数量的匹配。观察指标为院内并发症、死亡率、住院和重症监护病房的住院时间和呼吸机使用天数。

结果

我们匹配了 19638 名患者(AUD+:9819 名,AUD-:9819 名)。平均年龄为 53±22 岁,中位数损伤严重程度评分为 15[10-20]。匹配组在年龄(P=0.18)、吸烟状况(P=0.82)、损伤严重程度评分(P=0.28)、胸部损伤严重程度评分(P=0.24)和肋骨骨折数量(2[1-4]与 2[1-4],P=0.86)方面相似。酒精组肺炎发生率较高(18.1%比 9.2%,P<0.01),计划性插管率较高(18.5%比 9.7%,P<0.001),脓毒症发生率较高(10.8%比 6.3%,P<0.001),急性呼吸窘迫综合征发生率较高(12.2%比 7.4%,P<0.001),死亡率较高(8.0%比 5.7%,P<0.001)。AUD 患者在医院和重症监护病房的住院时间较长。两组呼吸机使用天数无差异。

结论

有肋骨骨折的 AUD 患者比没有 AUD 的患者不良事件发生率更高。早期识别有肋骨骨折的 AUD 患者可能有助于更好地分配资源,并有助于改善结局。

证据水平

III 级预后。

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