Lazova Snezhina, Velikova Tsvetelina, Priftis Stamatios, Petrova Guergana
Pediatric Department, UMHATEM "N. I. Pirogov", 21 Totleben blvd, 1606 Sofia, Bulgaria.
Sofia University-Medical Faculty, University Hospital Lozenets, 1 Kozyak str, 1407 Sofia, Bulgaria.
Antibodies (Basel). 2020 Jul 6;9(3):31. doi: 10.3390/antib9030031.
(1) Background: Asthma is a complex heterogeneous disease that likely comprises several distinct disease phenotypes, where the clustering approach has been used to classify the heterogeneous asthma population into distinct phenotypes; (2) Methods: For a period of 1 year, we evaluated medical history data of 71 children with asthma aged 3 to 17 years, performing pulmonary function tests, drew blood for IgE antibodies against inhalation and food allergies detection, and Asthma Control Questionnaire (ACQ); (3) Results: Five distinct phenotypes were determined. Cluster 1 (n = 10): (non-atopic) the lowest IgE level, very low ACQ, and median age of diagnosis. Cluster 2 (n = 28): (mixed) the highest Body mass index (BMI) with the latest age of diagnosis and high ACQ and bronchodilator response (BDR) levels and median and IgE levels. Cluster 3 (n = 19) (atopic) early diagnosis, highest BDR, highest ACQ score, highest total, and high specific IgE levels among the clusters. Cluster 4 (n = 9): (atopic) the highest specific IgE result, relatively high BMI, and IgE with median ACQ score among clusters. Cluster 5 (n = 5): (non-atopic) the earliest age for diagnosis, with the lowest BMI, the lowest ACQ score, and specific IgE levels, with high BDR and the median level of IgE among clusters; (4) Conclusions: We identified asthma phenotypes in Bulgarian children according to IgE levels, ACQ score, BDR, and age of diagnosis.
(1) 背景：哮喘是一种复杂的异质性疾病，可能包含几种不同的疾病表型，聚类方法已被用于将异质性哮喘人群分类为不同的表型；(2) 方法：在1年的时间里，我们评估了71名3至17岁哮喘儿童的病史数据，进行了肺功能测试，抽取血液检测针对吸入性和食物过敏的IgE抗体，以及哮喘控制问卷（ACQ）；(3) 结果：确定了五种不同的表型。第1组（n = 10）：（非特应性）IgE水平最低，ACQ极低，诊断年龄中位数。第2组（n = 28）：（混合型）体重指数（BMI）最高，诊断年龄最晚，ACQ和支气管扩张剂反应（BDR）水平高，IgE水平中位数。第3组（n = 19）（特应性）早期诊断，BDR最高，ACQ评分最高，总IgE最高，且在各群组中特异性IgE水平高。第4组（n = 9）：（特应性）特异性IgE结果最高，BMI相对较高，ACQ评分中位数。第5组（n = 5）：（非特应性）诊断年龄最早，BMI最低，ACQ评分最低，特异性IgE水平最低，BDR高，IgE水平中位数；(4) 结论：我们根据IgE水平、ACQ评分、BDR和诊断年龄确定了保加利亚儿童的哮喘表型。
