Smirnova O V, Oleĭnik N V, El'chaninova S A, Rozen V B
Probl Endokrinol (Mosk). 1988 Jul-Aug;34(4):68-72.
The paper is concerned with differential quantification of the level of androgen receptors (AR) in the liver cytosol of male and female rats as well as in the prostatic cytosol. AR affinity to synthetic androgen R1881 was shown to be similar in all investigated tissues. In male rats the AR content in the liver cytosol was 20.5 +/- 2.1 fmol per 1 mg of protein, lower (p less than 0.05) than in the prostatic cytosol (30.8 +/- 2.5 fmol per 1 mg of protein). Sex differentiation of the liver AR content with 3-fold predominance in males was determined. Gonadectomy of mature rats caused leveling down of sex differences in the liver AR content as a result of a decrease in AR concentration in castrated males and its increase in ovariectomized females. Sex differentiation of the liver AR content could be an additional factor enhancing the multiple differentiating action of androgens on the male rat liver.
本文关注雄性和雌性大鼠肝胞质溶胶以及前列腺胞质溶胶中雄激素受体（AR）水平的差异定量。结果表明，在所有研究组织中，AR对合成雄激素R1881的亲和力相似。雄性大鼠肝胞质溶胶中的AR含量为每1毫克蛋白质20.5±2.1飞摩尔，低于前列腺胞质溶胶（每1毫克蛋白质30.8±2.5飞摩尔，p<0.05）。确定了肝脏AR含量的性别分化，雄性含量占主导地位，为雌性的3倍。成熟大鼠去势导致肝脏AR含量的性别差异减小，原因是去势雄性大鼠的AR浓度降低，而卵巢切除雌性大鼠的AR浓度升高。肝脏AR含量的性别分化可能是增强雄激素对雄性大鼠肝脏多重分化作用的一个额外因素。
