Oleĭnik N V, Smirnova O V, Rozen V B
Probl Endokrinol (Mosk). 1990 May-Jun;36(3):61-6.
A study was made of the specificities of polydifferentiating action of androgens (A) and estrogens (E) on the level of androgen receptors (AR) of the rat liver cytosol. Androgen receptors were shown to be detected in the neonatal period of ontogenesis, their level was progressively on the increase with the body development. Sex differences in their content were revealed in mature animals only. The AR level is a reversibly controlled, but unprogrammed sex-related sign. The effects of sex steroids are dose-related and modulated reciprocally by the action of endogenous A and E. The action of physiological doses of A and E is characterized by slow development of the effect. Correlation between the level of AR and the efficacy of A action on the content of these proteins was revealed.
对雄激素（A）和雌激素（E）对大鼠肝脏细胞质雄激素受体（AR）水平的多向分化作用特异性进行了研究。结果表明，在个体发育的新生儿期可检测到雄激素受体，其水平随身体发育而逐渐升高。仅在成熟动物中发现其含量存在性别差异。AR水平是一个可逆控制但无程序的性别相关指标。性类固醇的作用与剂量相关，并受内源性A和E的作用相互调节。生理剂量的A和E的作用特点是作用起效缓慢。发现AR水平与A对这些蛋白质含量的作用效果之间存在相关性。
