Kalsi R, Pande K, Bhalla T N, Parmar S S, Barthwal J P
Jawahar Lal Nehru Laboratory of Molecular Biology, Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
Pharmacology. 1988;37(4):218-24. doi: 10.1159/000138469.
Various new substituted formazans were synthesized and characterized by elemental analyses, IR and mass spectral data. The compounds were evaluated for their ability to protect against inflammation by carrageenin-induced paw edema in albino rats of either sex. The active derivatives of the present series were also tested for their analgesic activity against aconitine-induced writhing in albino mice and ulcerogenic activity in albino rats. The toxicity of the compounds was assessed by determination of their approximate LD50 on albino mice. An attempt has also been made to establish a structure-activity relationship.
合成了各种新的取代甲臜，并通过元素分析、红外光谱和质谱数据对其进行了表征。通过角叉菜胶诱导的雌雄白化大鼠爪肿胀来评估这些化合物的抗炎能力。还测试了本系列活性衍生物对白化小鼠乌头碱诱导的扭体反应的镇痛活性以及对白化大鼠的致溃疡活性。通过测定化合物对白化小鼠的近似半数致死量来评估其毒性。还尝试建立构效关系。
