Pande K, Tandon M, Bhalla T N, Parmar S S, Barthwal J P
Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
Pharmacology. 1987;35(6):333-8. doi: 10.1159/000138358.
Various new tetrazoles were tested for their anti-inflammatory activity against carrageenin-induced paw oedema in albino rats. Among these, two most potent derivatives were evaluated in detail using cotton pellet implantation methods in albino rats of either sex. These two active analogues were also tested for their analgesic activity in albino mice and ulcerogenic liability in albino rats. All derivatives of the present series were evaluated for their antiproteolytic activity. The toxicity of the compounds was assessed by determination of their approximate LD50 in albino mice. An attempt has also been made to establish the structure activity relationship.
测试了各种新型四氮唑对白化病大鼠角叉菜胶诱导的爪肿胀的抗炎活性。其中，使用棉球植入法在雄性和雌性白化病大鼠中详细评估了两种最有效的衍生物。还对白化病小鼠测试了这两种活性类似物的镇痛活性，对白化病大鼠测试了其致溃疡倾向。评估了本系列所有衍生物的抗蛋白水解活性。通过测定化合物在白化病小鼠中的近似半数致死量（LD50）来评估其毒性。还尝试建立构效关系。
