检测人类脑炎病例中的伪狂犬病病毒抗体。

Detection of Pseudorabies Virus Antibodies in Human Encephalitis Cases.

机构信息

National Research Center for Veterinary Medicine, Luoyang 471003, Henan, China.

Department of Viral Encephalitis, NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

出版信息

Biomed Environ Sci. 2020 Jun 20;33(6):444-447. doi: 10.3967/bes2020.059.

DOI:10.3967/bes2020.059

PMID:32641207

Abstract

Pseudorabies virus (PRV), a veterinary pathogen that infects domestic animals as well as wild animals such as wild boar and feral swine, was recently reported to infect human and led to endophthalmitis and encephalitis. A retrospective seroepidemiologic survey was conducted using 1,335 serum samples collected from patients with encephalitis and ELISA positive rates were 12.16%, 14.25%, and 6.52% in 2012, 2013, and 2017, respectively. The virus neutralizing antibody titers of positive samples correlated well with ELISA results. The pseudorabies virus antibody positive rate of patients with encephalitis were higher than that of healthy people in 2017. The above results suggest that some undefined human encephalitis cases may be caused by PRV infection.

摘要

伪狂犬病病毒（PRV）是一种兽医病原体，可感染家畜以及野猪和野猪等野生动物，最近有报道称该病毒可感染人类，并导致眼内炎和脑炎。我们使用从脑炎患者中采集的 1335 份血清样本进行了回顾性血清流行病学调查，ELISA 阳性率在 2012 年、2013 年和 2017 年分别为 12.16%、14.25%和 6.52%。阳性样本的病毒中和抗体滴度与 ELISA 结果相关性良好。2017 年脑炎患者的伪狂犬病病毒抗体阳性率高于健康人群。上述结果表明，某些未明原因的人类脑炎病例可能是由 PRV 感染引起的。