Pal Amit, Pawar Anil, Goswami Kalyan, Sharma Praveen, Prasad Rajendra
Department of Biochemistry, AIIMS, Kalyani, 741235 West Bengal India.
Department of Zoology, DAV University, Jalandhar, 144012 Punjab India.
Indian J Clin Biochem. 2020 Jul;35(3):274-284. doi: 10.1007/s12291-020-00900-x. Epub 2020 Jun 10.
As the time for finding a definitive and safe cure as a vaccine for novel Corona Virus Disease 2019 (Covid-19) is still far, there is need to study in depth about the other potential drugs, which can save millions of lives due to Covid-19 pandemic. Right at the center of the debate is the use of drug "Hydroxychloroquine" as a prophylaxis as well as a treatment strategy against Covid-19 in conjunction with azithromycin. In this review, we will study the cellular and molecular aspects of hydroxychloroquine, which had driven its use in Covid-19 patients, as well as its chemistry and pharmacokinetics along with clinical trials going on worldwide using hydroxychloroquine against Covid-19.
由于找到一种确定且安全的新型冠状病毒肺炎（COVID-19）疫苗作为治愈方法的时间仍遥遥无期，因此有必要深入研究其他潜在药物，这些药物可以在COVID-19大流行中拯救数百万人的生命。争论的焦点正是药物“羟氯喹”作为预防措施以及与阿奇霉素联合用于治疗COVID-19的策略。在这篇综述中，我们将研究羟氯喹在COVID-19患者中使用的细胞和分子层面，以及它的化学性质、药代动力学，还有全球范围内正在进行的使用羟氯喹治疗COVID-19的临床试验。
