Liu Shuiping, Zhuo Lvjia, Wang Jianjun, Zhang Qin, Li Qiujie, Li Guohua, Yan Lili, Jin Ting, Pan Ting, Sui Xinbing, Lv Qun, Xie Tian
Holistic Integrative Pharmacy Institutes of Medicine School, Department of Respiratory Medicine of Affiliated Hospital, Hangzhou Normal University Hangzhou 311121, Zhejiang, China.
Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province & Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province & Collaborative Innovation Center of Traditional Chinese Medicines from Zhejiang Province, Hangzhou Normal University Hangzhou 311121, Zhejiang, China.
Am J Cancer Res. 2020 Jun 1;10(6):1631-1646. eCollection 2020.
N-methyladenosine (mA) is the most common internal modification of mRNAs in higher eukaryotic. This process is performed by methyltransferase. Methyltransferase-like 3 (METTL3) is the best known mA methyltransferase that functions in the reversible epi-transcriptome modulation of mA modification. Besides acting as a mA methyltransferase, METTL3 also regulates mRNA translation and other biological processes. In recent years, studies have identified numerous roles and molecular mechanisms associated with METTL3 in multiple biological processes. However, these findings have not been summarized. In this review, we have systematically summarized the most recent important roles of METTL3 in various biological processes, including cell cycle progression, cell proliferation, cell apoptosis, cell migration and invasion, cell differentiation and inflammatory response. In addition, we discuss the prospect of using a METTL3 as a new diagnostic biomarker and therapeutic target for human cancers.
N-甲基腺苷（mA）是高等真核生物中最常见的mRNA内部修饰。该过程由甲基转移酶完成。类甲基转移酶3（METTL3）是最著名的mA甲基转移酶，在mA修饰的可逆表观转录组调控中发挥作用。除了作为mA甲基转移酶外，METTL3还调节mRNA翻译和其他生物学过程。近年来，研究已经确定了METTL3在多种生物学过程中的众多作用和分子机制。然而，这些发现尚未得到总结。在本综述中，我们系统地总结了METTL3在各种生物学过程中最新的重要作用，包括细胞周期进程、细胞增殖、细胞凋亡、细胞迁移和侵袭、细胞分化以及炎症反应。此外，我们还讨论了将METTL3用作人类癌症新诊断生物标志物和治疗靶点的前景。
