Schwartzman R J, Alexander G M, Ferraro T N, Grothusen J R, Stahl S M
Department of Neurology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Exp Neurol. 1988 Dec;102(3):307-13. doi: 10.1016/0014-4886(88)90224-5.
This study evaluates the changes in the local cerebral metabolic rate for glucose (LCMRg) in primates exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The LCMRg was evaluated 21 days following the last dose of MPTP. At this time, all MPTP-injected animals demonstrated parkinsonism and striatal dopamine was reduced to less than 3% of control values. The structures whose LCMRg was most affected were the motor cortex, the intermediate zone of the putamen, the external segment of the globus pallidus, the medial part of the ventrolateral nucleus of the thalamus (VLm), visual cortex, locus ceruleus, and the dorsolateral segment of the substantia nigra pars compacta. The structure whose increase in LCMRg correlated most closely to the clinical severity of parkinsonism was the external segment of the globus pallidus.
本研究评估了暴露于1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）的灵长类动物局部脑葡萄糖代谢率（LCMRg）的变化。在最后一剂MPTP注射21天后评估LCMRg。此时，所有注射MPTP的动物均表现出帕金森综合征，纹状体多巴胺减少至对照值的3%以下。LCMRg受影响最大的结构是运动皮层、壳核中间区、苍白球外侧段、丘脑腹外侧核内侧部（VLm）、视觉皮层、蓝斑以及黑质致密部背外侧段。LCMRg增加与帕金森综合征临床严重程度最密切相关的结构是苍白球外侧段。
