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蓝色橡皮疱痣综合征：胃肠道出血的罕见病因。

Blue rubber bleb naevus disease: an uncommon cause of gastrointestinal tract bleeding.

作者信息

Jennings M, Ward P, Maddocks J L

机构信息

University Department of Pharmacology and Therapeutics, Royal Hallamshire Hospital, Sheffield.

出版信息

Gut. 1988 Oct;29(10):1408-12. doi: 10.1136/gut.29.10.1408.

DOI:10.1136/gut.29.10.1408
PMID:3264257
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1434013/
Abstract

A 23 year old woman presented with facial pain, a right parotid tumour and iron deficiency anaemia. She had several cutaneous venous swellings and tumours with a similar appearance were found in the large bowel. Histological examination of the parotid tumour and angiography of the skin and gut lesions confirmed that they were venous in origin. The aetiology, classification, and complications of disorders of the venous system and the importance of using a tourniquet to examine the peripheral veins is discussed.

摘要

一名23岁女性出现面部疼痛、右侧腮腺肿瘤和缺铁性贫血。她有多处皮肤静脉肿胀，在大肠中发现了外观相似的肿瘤。腮腺肿瘤的组织学检查以及皮肤和肠道病变的血管造影证实它们起源于静脉。本文讨论了静脉系统疾病的病因、分类和并发症，以及使用止血带检查外周静脉的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/1615d76e6c6f/gut00236-0128-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/c7b8d64faa52/gut00236-0126-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/d857c3fda203/gut00236-0127-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/fe19d02eb6cc/gut00236-0127-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/9261cb2b035f/gut00236-0127-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/406ef339f9ae/gut00236-0127-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/59e238e93e52/gut00236-0128-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/3d8be32105e0/gut00236-0128-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/f4848592122f/gut00236-0128-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/1615d76e6c6f/gut00236-0128-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/c7b8d64faa52/gut00236-0126-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/d857c3fda203/gut00236-0127-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/fe19d02eb6cc/gut00236-0127-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/9261cb2b035f/gut00236-0127-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/406ef339f9ae/gut00236-0127-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/59e238e93e52/gut00236-0128-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/3d8be32105e0/gut00236-0128-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/f4848592122f/gut00236-0128-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f726/1434013/1615d76e6c6f/gut00236-0128-d.jpg

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引用本文的文献

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An unusual and challenging cause of small bowel bleeding: Isolated gastrointestinal blue rubber bleb nevus syndrome.小肠出血的一种罕见且具有挑战性的病因：孤立性胃肠道蓝色橡皮疱痣综合征。
Transl Gastroenterol Hepatol. 2022 Jan 25;7:12. doi: 10.21037/tgh.2020.02.19. eCollection 2022.
2
Blue rubber bleb naevus syndrome: a rare cause of chronic occult blood loss and iron deficiency anaemia.蓝色橡皮疱痣综合征：慢性隐匿性失血和缺铁性贫血的罕见病因。
BMJ Case Rep. 2016 Dec 20;2016:bcr2016216963. doi: 10.1136/bcr-2016-216963.
3
Synchronous multiple small bowel intussusceptions in an adult with blue rubber bleb naevus syndrome: Report of a case and review of literature.

本文引用的文献

1
HAEMANGIOMA OF THE SPINAL CORD: ASSOCIATED WITH SKIN NAEVI OF THE SAME METAMERE.脊髓血管瘤：与同一节段的皮肤痣相关。
Ann Surg. 1915 Dec;62(6):641-9. doi: 10.1097/00000658-191512000-00001.
2
A case of haemangiomatosis of the small intestine.一例小肠血管瘤病
Br J Surg. 1952 Mar;39(157):462-3. doi: 10.1002/bjs.18003915714.
3
Haemangiomata of the intestine.肠道血管瘤
成人蓝色橡皮疱痣综合征合并多发小肠套叠 1 例并文献复习
World J Emerg Surg. 2008 Jan 18;3:3. doi: 10.1186/1749-7922-3-3.
4
A case of blue rubber bleb nevus syndrome treated by etidronate.
J Bone Miner Metab. 2007;25(2):138-41. doi: 10.1007/s00774-006-0740-x. Epub 2007 Feb 26.
Br Med J. 1951 Mar 24;1(4707):620-1. doi: 10.1136/bmj.1.4707.620.
4
CONGENITAL ANGIODYSPLASIAS OF THE EXTREMITIES. I. GENERALITIES AND CLASSIFICATION; VENOUS DYSPLASIAS.肢体先天性血管发育异常。I. 概述与分类；静脉发育异常
J Cardiovasc Surg (Torino). 1964 Mar-Apr;5:87-130.
5
Blue rubber-bleb nevus syndrome. Generalized cavernous hemangiomatosis or venous hamartoma with medulloblastoma of the cerebellum: case report and review of the literature.
Arch Dermatol. 1962 Oct;86:503-11. doi: 10.1001/archderm.1962.01590100117021.
6
Blue rubber bleb nevus.
Arch Dermatol. 1961 Nov;84:802-5. doi: 10.1001/archderm.1961.01580170096013.
7
Disappearing bones: a rare form of massive osteolysis; report of two cases, one with autopsy findings.骨质消失：一种罕见的广泛性骨质溶解形式；两例报告，其中一例有尸检结果。
Am J Med. 1954 Nov;17(5):674-82. doi: 10.1016/0002-9343(54)90027-3.
8
Blue rubber bleb naevus.蓝色橡皮疱痣
Br Med J. 1966 Oct 15;2(5519):931-2. doi: 10.1136/bmj.2.5519.931.
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Blue rubber bleb nevus.
Arch Intern Med. 1965 Dec;116(6):924-9.
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Blue rubber bleb naevi (report of a family in which only males were affected).
Br J Dermatol. 1970 Jan;82(1):37-9. doi: 10.1111/j.1365-2133.1970.tb02191.x.