与帕尼单抗治疗转移性结直肠癌相关的瘢痕性睑外翻和睫毛脱落
Cicatricial ectropion and madarosis associated with panitumumab treatment of metastatic colorectal cancer.
作者信息
Jin Haoxing D, Blessing Nathan W
机构信息
Dean McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
出版信息
Am J Ophthalmol Case Rep. 2020 Jun 30;19:100810. doi: 10.1016/j.ajoc.2020.100810. eCollection 2020 Sep.
PURPOSE
To report a case of cicatricial ectropion and madarosis with the use of anti-epidermal growth factor receptor medication panitumumab.
OBSERVATIONS
An 82-year-old man with metastatic colorectal cancer presented with cicatricial ectropion and madarosis after starting panitumumab, an anti-epidermal growth factor receptor medication used to treat metastatic colorectal cancer. His findings resolved several weeks after discontinuation of panitumumab and treatment with lubrication and antibiotic/steroid ointment.
CONCLUSION
This case demonstrates the importance to consider potential medication side effects when treating periocular conditions in patients taking anti-epidermal growth factor receptor (anti-EGFR) agents.
目的
报告一例使用抗表皮生长因子受体药物帕尼单抗后出现瘢痕性睑外翻和睫毛脱落的病例。
观察结果
一名82岁的转移性结直肠癌男性患者，在开始使用用于治疗转移性结直肠癌的抗表皮生长因子受体药物帕尼单抗后出现瘢痕性睑外翻和睫毛脱落。在停用帕尼单抗并使用润滑剂及抗生素/类固醇眼膏治疗数周后，他的症状得到缓解。
结论
该病例表明，在治疗使用抗表皮生长因子受体（抗EGFR）药物患者的眼周疾病时，考虑潜在药物副作用的重要性。
Zotero 插件