Ferguson Tanner J, Traboulsi Elias I, Goshe Jeffrey M
Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
Am J Ophthalmol Case Rep. 2020 Jun 30;19:100812. doi: 10.1016/j.ajoc.2020.100812. eCollection 2020 Sep.
To report a case of a successful Descemet's membrane endothelial keratoplasty (DMEK) facilitated by the use of intracameral tissue plasminogen activator (tPA) in a 4-year old with posterior polymorphous corneal dystrophy (PPCD).
A 4-year old male was referred for bilateral corneal haze and blurry vision. Patient's exam and genetic testing were consistent with a diagnosis of PPCD. Patient was successfully treated with DMEK augmented by the use of intracameral tPA intraoperatively to combat the anterior chamber fibrin formation that can occur in DMEK.
To our knowledge, this case represents the youngest reported successful DMEK procedure and the first case describing the use of intracameral tPA intraoperatively to attenuate the anterior chamber fibrin formation that can occur in DMEK.
报告一例在一名4岁患有后弹力层多形性角膜营养不良（PPCD）的患儿中，通过前房内使用组织纤溶酶原激活剂（tPA）辅助成功进行Descemet膜内皮角膜移植术（DMEK）的病例。
一名4岁男性因双侧角膜混浊和视力模糊前来就诊。患者的检查和基因检测结果与PPCD的诊断相符。术中通过前房内使用tPA辅助DMEK成功治疗该患者，以对抗DMEK手术中可能出现的前房纤维蛋白形成。
据我们所知，该病例是报道的最年轻的成功进行DMEK手术的病例，也是首例描述术中使用前房内tPA减轻DMEK手术中可能出现的前房纤维蛋白形成的病例。
