Department of Gynecology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, 310003, People's Republic of China.
Arch Gynecol Obstet. 2020 Sep;302(3):553-567. doi: 10.1007/s00404-020-05664-6. Epub 2020 Jul 8.
To analyze the effect of Chlamydia trachomatis (C. trachomatis) on adverse pregnancy outcomes based on the currently available evidence.
Multiple databases were comprehensively searched from the available date of inception through December 9, 2019. The effect of C. trachomatis on adverse pregnancy outcomes was assessed using pooled odds rations (ORs) and 95% confidence intervals (CIs). Egger's test was used for publication bias.
Fifty studies involving 502,141 participants were identified. C. trachomatis infection was found to be associated with preterm birth in antibody detection [OR (95% CI): 1.571 (1.112-2.220), P = 0.010] and high-quality assessment [OR (95% CI): 1.734 (1.295-2.321), P < 0.001], preterm premature rupture of membranes (PPROM) in culture detection [OR (95% CI): 4.339 (1.806-10.424), P = 0.001] and high-quality assessment [OR (95% CI): 2.822 (1.333-5.973), P = 0.007], stillbirth [OR (95% CI): 1.585 (1.219-2.062), P = 0.001], low-birthweight babies [OR (95% CI): 2.205 (1.137-4.274), P = 0.019], and babies small for gestational age [OR (95% CI): 1.193 (1.091-1.305), P < 0.001]. No publication bias was exhibited in miscarriage (P = 0.170), preterm birth (P = 0.303), PPROM (P = 0.341), stillbirth (P = 0.533), and low-birthweight babies (P = 0.535).
C. trachomatis infection during pregnancy is associated with a higher risk of preterm birth, PPROM, stillbirth, low-birthweight babies, and babies small for gestational age.
基于现有证据分析沙眼衣原体（C. trachomatis）对不良妊娠结局的影响。
全面检索了从可用数据开始到 2019 年 12 月 9 日的多个数据库。使用合并优势比（ORs）和 95%置信区间（CIs）评估 C. trachomatis 对不良妊娠结局的影响。采用 Egger 检验评估发表偏倚。
共确定了 50 项涉及 502141 名参与者的研究。抗体检测发现沙眼衣原体感染与早产有关[OR（95%CI）：1.571（1.112-2.220），P=0.010]和高质量评估[OR（95%CI）：1.734（1.295-2.321），P<0.001]，培养检测发现早产胎膜早破（PPROM）[OR（95%CI）：4.339（1.806-10.424），P=0.001]和高质量评估[OR（95%CI）：2.822（1.333-5.973），P=0.007]，死胎[OR（95%CI）：1.585（1.219-2.062），P=0.001]，低出生体重儿[OR（95%CI）：2.205（1.137-4.274），P=0.019]和小于胎龄儿[OR（95%CI）：1.193（1.091-1.305），P<0.001]。流产（P=0.170）、早产（P=0.303）、PPROM（P=0.341）、死胎（P=0.533）和低出生体重儿（P=0.535）均未显示发表偏倚。
妊娠期沙眼衣原体感染与早产、PPROM、死胎、低出生体重儿和小于胎龄儿的风险增加相关。
