College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China.
Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Science, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032, China.
Org Lett. 2020 Jul 17;22(14):5451-5455. doi: 10.1021/acs.orglett.0c01826. Epub 2020 Jul 9.
The oxidative C-H aryloxydifluoromethylation and arylthiodifluoromethylation of heteroaromatic compounds through the decarboxylation of easily accessible aryloxydifluoroacetic acids and arylthiodifluoroacetic acids, respectively, are disclosed. These reactions are promoted by the combination of catalytic AgNO and Selectfluor or KSO to give ArOCF- and ArSCF-substituted heteroaromatic compounds in moderate to high yields.
本文公开了通过易于获得的芳氧基二氟乙酸和芳基硫代二氟乙酸的脱羧反应，分别实现杂芳环化合物的氧化 C-H 芳氧基二氟甲基化和芳基硫代二氟甲基化。这些反应在催化 AgNO 和 Selectfluor 或 KSO 的组合促进下，以中等至高产率得到 ArOCF-和 ArSCF 取代的杂芳环化合物。
