Levine S, Saltzman A
Department of Pathology, New York Medical College, Valhalla.
Lymphology. 1988 Sep;21(3):161-8.
Injection of mercuric chloride caused a progressive systemic lymphadenopathy and splenomegaly in Brown Norway (BN) but not in Lewis rats, as reported by others. We studied the number, duration and route of HgCl2 treatments and the topography of the resultant lymphadenopathy, as well as its age and strain dependency. Five injections of HgCl2 increased three-fold the weight of the lymph nodes which became considerably heavier than the spleen. Weanling rats were less susceptible than adults. A regional lymphadenopathy could not be produced. However, a synergistic interaction was observed when the systemic effects of HgCl2 were added to the regional lymphadenopathy produced by injections of metal powders, such that the lymph node mass approached 2% of body weight.
如其他人所报道，注射氯化汞会导致棕色挪威（BN）大鼠出现进行性全身淋巴结病和脾肿大，但不会导致刘易斯大鼠出现这种情况。我们研究了氯化汞治疗的次数、持续时间和途径以及由此产生的淋巴结病的形态，以及其年龄和品系依赖性。五次注射氯化汞使淋巴结重量增加了三倍，淋巴结变得比脾脏重得多。断奶大鼠比成年大鼠更不易感。无法产生局部淋巴结病。然而，当将氯化汞的全身效应与注射金属粉末产生的局部淋巴结病相加时，观察到了协同相互作用，使得淋巴结质量接近体重的2%。
