Pelletier L, Pasquier R, Hirsch F, Sapin C, Druet P
Eur J Immunol. 1985 May;15(5):460-5. doi: 10.1002/eji.1830150509.
Mercuric chloride induces in Brown-Norway rats a polyclonal activation of B cells resulting in a lymphoproliferation and in the production of autoantibodies. Experiments were performed to test the role of cells modified by HgCl2 in the induction of B cell proliferation by using the popliteal lymph node assay. Spleen cells, T cells and peritoneal macrophages exposed in vivo or in vitro to HgCl2 induced a proliferation of T and B cells in the draining popliteal lymph node. Spleen cells from Lewis rats who received HgCl2 were ineffective. These data suggest that modified cells could trigger autologous lymphocyte subsets and be responsible for autoimmunity induced by HgCl2.
氯化汞可诱导棕色挪威大鼠的B细胞发生多克隆激活，导致淋巴细胞增殖并产生自身抗体。通过腘窝淋巴结试验进行实验，以测试经HgCl2修饰的细胞在诱导B细胞增殖中的作用。体内或体外暴露于HgCl2的脾细胞、T细胞和腹腔巨噬细胞可诱导引流腘窝淋巴结中的T细胞和B细胞增殖。接受HgCl2的Lewis大鼠的脾细胞无效。这些数据表明，修饰的细胞可触发自体淋巴细胞亚群，并导致由HgCl2诱导的自身免疫。
