Department of Dermatology, Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
Department of Pathology, Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
J Cutan Pathol. 2020 Nov;47(11):1026-1032. doi: 10.1111/cup.13801. Epub 2020 Sep 8.
Non-neural granular cell tumor (NNGCT) is an uncommon neoplasm of controversial histogenesis and its histopathologic differential diagnosis includes, in addition to conventional GCT, other dermal tumors that may exhibit granular cell change.
Three patients with a diagnosis of NNGCT were identified in the authors' files. Hematoxylin and eosin-stained sections and immunohistochemical studies were performed.
Histopathological study of the three lesions showed dermal proliferation of granular cells arranged in thick fascicles between collagen bundles. The lesions showed positivity for Factor XIIIa, CD163, CD68, NKIC3, vimentin, ALK, fascin, and cyclin D1.
To our knowledge, positivity for cyclin D1 has not been reported to date in NNGCT. In borderline cases, where the diagnosis is unclear despite histopathologic and immunohistochemical findings, positivity for cyclin D1 may favor the diagnosis of NNGCT. Further investigations to assess the differentiation of this rare neoplasm are needed.
非神经颗粒细胞瘤（NNGCT）是一种罕见的肿瘤，其组织发生存在争议，其组织病理学鉴别诊断除了常规的 GCT 外，还包括可能表现出颗粒细胞变化的其他皮肤肿瘤。
作者在自己的档案中确定了 3 名 NNGCT 患者。进行了苏木精和伊红染色切片和免疫组织化学研究。
对三个病变的组织病理学研究显示，颗粒细胞在胶原束之间的厚束中呈真皮性增殖。这些病变对因子 XIIIa、CD163、CD68、NKIC3、波形蛋白、ALK、 fascin 和 cyclin D1 呈阳性。
据我们所知，目前尚未有关于 NNGCT cyclin D1 阳性的报道。在交界性病例中，尽管组织病理学和免疫组织化学发现不明确，cyclin D1 的阳性可能有利于 NNGCT 的诊断。需要进一步的研究来评估这种罕见肿瘤的分化。
