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噬菌体在食品生产和加工中的生物防治应用。

Phage Biocontrol Applications in Food Production and Processing.

机构信息

Intralytix, Inc., Columbia, Maryland 21046, USA.

出版信息

Curr Issues Mol Biol. 2021;40:267-302. doi: 10.21775/cimb.040.267. Epub 2020 Jul 9.

Abstract

Bacteriophages, or phages, are one of the most, if not the most, ubiquitous organisms on Earth. Interest in various practical applications of bacteriophages has been gaining momentum recently, with perhaps the most attention (and most regulatory approvals) focused on their use to improve food safety. This approach, termed 'phage biocontrol' or 'bacteriophage biocontrol', includes both pre- and post-harvest application of phages as well as decontamination of the food contact surfaces in food processing facilities. This review focuses on post-harvest applications of phage biocontrol, currently the most commonly used type of phage mediation. We also briefly describe various commercially available phage preparations and discuss the challenges still facing this novel yet promising approach.

摘要

噬菌体,或 phages,是地球上最广泛存在的生物之一,如果不是最广泛存在的话。最近,人们对噬菌体的各种实际应用产生了浓厚的兴趣,其中也许最受关注(也获得了最多的监管批准)的是它们在提高食品安全方面的应用。这种方法被称为“噬菌体生物控制”或“噬菌体生物防治”,包括在收获前和收获后应用噬菌体以及在食品加工设施中对食品接触面进行消毒。本综述重点介绍噬菌体生物防治的收获后应用,这是目前最常用的噬菌体介导类型。我们还简要描述了各种市售的噬菌体制剂,并讨论了这种新颖但有前途的方法仍然面临的挑战。

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