Efenberger-Szmechtyk Magdalena, Nowak Agnieszka
Institute of Fermentation Technology and Microbiology, Lodz University of Technology, Wolczanska 171/173, 90-530 Lodz, Poland.
Molecules. 2025 Sep 6;30(17):3641. doi: 10.3390/molecules30173641.
Lytic bacteriophages, viruses that attack and kill bacteria cells, can be used in food as biocontrol agents to prevent the growth of pathogenic bacteria. Meat is highly susceptible to bacterial growth, including pathogenic species, the control of which is crucial. Antibiotic use by breeders has resulted in bacterial resistance, which remains a huge problem; bacteriophages have emerged as an interesting alternative. In the literature, the influence of bacteriophages on common foodborne pathogens, such as sp., , , , , and sp., has been described. Some phage preparations can show synergistic effects when used with other antimicrobial agents. However, data on the use of bacteriophages to inhibit the growth of meat spoilage bacteria are limited. Bacteriophages can also synthesize endolysins, which possess antimicrobial properties. Contrary to bacteriophages, which are active against only a narrow range of microorganisms (usually one bacterial species), endolysins show a broad spectrum of activity.
裂解性噬菌体是一种攻击并杀死细菌细胞的病毒,可作为生物防治剂用于食品中,以防止病原菌生长。肉类极易受到细菌生长的影响,包括病原菌,控制病原菌的生长至关重要。养殖者使用抗生素已导致细菌产生耐药性,这仍然是一个巨大的问题;噬菌体已成为一种有趣的替代方案。在文献中,已描述了噬菌体对常见食源性病原体的影响,如 、 、 、 、 、 以及 。一些噬菌体制剂与其他抗菌剂联合使用时可显示协同效应。然而,关于使用噬菌体抑制肉类腐败细菌生长的数据有限。噬菌体还可合成具有抗菌特性的内溶素。与仅对窄范围微生物(通常为一种细菌物种)具有活性的噬菌体不同,内溶素具有广谱活性。