Erythropoietin-induced hemoglobin subunit beta may stimulate innate immune RNA virus pattern recognition, suppress reactive oxygen species, reduce ACE2 viral doorway opening, and neutrophil extracellular traps against COVID-19.
作者信息
Brenner Steven Robert
机构信息
Neurology Department (retired), Saint Louis Veterans Administration Hospital (retired), Saint Louis University (retired), St. Louis, Missouri.
出版信息
J Med Virol. 2021 Jan;93(1):180-181. doi: 10.1002/jmv.26284. Epub 2020 Jul 17.
Abstract
摘要
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Erythropoietin-induced hemoglobin subunit beta may stimulate innate immune RNA virus pattern recognition, suppress reactive oxygen species, reduce ACE2 viral doorway opening, and neutrophil extracellular traps against COVID-19.促红细胞生成素诱导的血红蛋白亚基β可能刺激先天性免疫RNA病毒模式识别、抑制活性氧、减少ACE2病毒入口开放以及针对新冠病毒的中性粒细胞胞外诱捕网。
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本文引用的文献
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Erythropoietin as candidate for supportive treatment of severe COVID-19.促红细胞生成素作为治疗严重 COVID-19 的支持性治疗候选药物。
Mol Med. 2020 Jun 16;26(1):58. doi: 10.1186/s10020-020-00186-y.
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Endothelial cell infection and endotheliitis in COVID-19.新型冠状病毒肺炎中的内皮细胞感染与内皮炎
Lancet. 2020 May 2;395(10234):1417-1418. doi: 10.1016/S0140-6736(20)30937-5. Epub 2020 Apr 21.
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Does recombinant human erythropoietin administration in critically ill COVID-19 patients have miraculous therapeutic effects?危重症 COVID-19 患者应用重组人促红细胞生成素治疗有神奇疗效吗？
J Med Virol. 2020 Jul;92(7):915-918. doi: 10.1002/jmv.25839. Epub 2020 Apr 19.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）进入细胞依赖于 ACE2 和 TMPRSS2，可被一种临床验证的蛋白酶抑制剂所阻断。
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
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Human Hemoglobin Subunit Beta Functions as a Pleiotropic Regulator of RIG-I/MDA5-Mediated Antiviral Innate Immune Responses.人血红蛋白亚基β作为 RIG-I/MDA5 介导的抗病毒先天免疫反应的多效调节因子发挥作用。
J Virol. 2019 Jul 30;93(16). doi: 10.1128/JVI.00718-19. Print 2019 Aug 15.
6
Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.血管紧张素转换酶2激活通过介导内皮型一氧化氮合酶磷酸化改善肺动脉高压大鼠的肺内皮功能障碍。
J Am Soc Hypertens. 2017 Dec;11(12):842-852. doi: 10.1016/j.jash.2017.10.009. Epub 2017 Oct 28.
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Erythropoietin and Its Angiogenic Activity.促红细胞生成素及其血管生成活性。
Int J Mol Sci. 2017 Jul 13;18(7):1519. doi: 10.3390/ijms18071519.
8
Endothelial cell expression of haemoglobin α regulates nitric oxide signalling.内皮细胞血红蛋白 α 的表达调节一氧化氮信号转导。
Nature. 2012 Nov 15;491(7424):473-7. doi: 10.1038/nature11626. Epub 2012 Oct 31.
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Hypoxia up-regulates expression of hemoglobin in alveolar epithelial cells.低氧上调肺泡上皮细胞中血红蛋白的表达。
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