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与 COVID-19 相关的神经系统表现及其可能的机制。

Nervous system manifestations related to COVID-19 and their possible mechanisms.

机构信息

The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China; Medical Research Center; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, No.10 Eastern section of the third FengCheng Rd., WeiYang District, Xi'an City, Shaanxi Province, P.R. China.

Department of Spine Surgery, Honghui Hospital, The Affiliated Hospital of Xi'an Jiaotong University, No. 555 Youyi East Road, Xi'an, Shaanxi 710054, PR China.

出版信息

Brain Res Bull. 2022 Sep;187:63-74. doi: 10.1016/j.brainresbull.2022.06.014. Epub 2022 Jun 28.

DOI:10.1016/j.brainresbull.2022.06.014
PMID:35772604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9236920/
Abstract

In December 2019, the novel coronavirus disease (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection broke. With the gradual deepening understanding of SARS-CoV-2 and COVID-19, researchers and clinicians noticed that this disease is closely related to the nervous system and has complex effects on the central nervous system (CNS) and peripheral nervous system (PNS). In this review, we summarize the effects and mechanisms of SARS-CoV-2 on the nervous system, including the pathways of invasion, direct and indirect effects, and associated neuropsychiatric diseases, to deepen our knowledge and understanding of the relationship between COVID-19 and the nervous system.

摘要

2019 年 12 月，新型冠状病毒病（COVID-19）由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引起。随着对 SARS-CoV-2 和 COVID-19 的逐渐深入了解，研究人员和临床医生注意到这种疾病与神经系统密切相关，对中枢神经系统（CNS）和周围神经系统（PNS）有复杂的影响。在这篇综述中，我们总结了 SARS-CoV-2 对神经系统的影响和机制，包括入侵途径、直接和间接影响以及相关的神经精神疾病，以加深我们对 COVID-19 与神经系统关系的认识和理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6320/9236920/2f9362899aee/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6320/9236920/5aca8aa8fb5c/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6320/9236920/2f9362899aee/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6320/9236920/5aca8aa8fb5c/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6320/9236920/2f9362899aee/gr2_lrg.jpg

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Nervous system manifestations related to COVID-19 and their possible mechanisms.

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引用本文的文献

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Acute and long-term effects of COVID-19 on brain and mental health: A narrative review.

Brain Behav Immun. 2025-1

[2]
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[3]
Research Trends in Proteomic Studies Using Serum from COVID-19 Patients: A Bibliometric Analysis.

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[4]
Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease.

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[5]
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本文引用的文献

[1]
Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue.

Biofactors. 2021-3

[2]
6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records.

Lancet Psychiatry. 2021-5

[3]
The Impact of COVID-19 on Patients With Neuromyelitis Optica Spectrum Disorder Beyond Infection Risk.

Front Neurol. 2021-3-22

[4]
Myasthenia gravis at the crossroad of COVID-19: focus on immunological and respiratory interplay.

Acta Neurol Belg. 2021-6

[5]
Case series of COVID-19 in patients with myasthenia gravis: a single institution experience.

Acta Neurol Belg. 2021-8

[6]
Neurological manifestations of COVID-19 in confirmed and probable cases: A descriptive study from a large tertiary care center.

J Clin Neurosci. 2021-4

[7]
Persistent neurologic symptoms and cognitive dysfunction in non-hospitalized Covid-19 "long haulers".

Ann Clin Transl Neurol. 2021-5

[8]
Neurological Consequences of SARS-CoV-2 Infection and Concurrence of Treatment-Induced Neuropsychiatric Adverse Events in COVID-19 Patients: Navigating the Uncharted.

Front Mol Biosci. 2021-2-18

[9]
SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders.

Cytokine Growth Factor Rev. 2021-4

[10]
Historical Insight into Infections and Disorders Associated with Neurological and Psychiatric Sequelae Similar to Long COVID.

Med Sci Monit. 2021-2-26

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