The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China; Medical Research Center; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, No.10 Eastern section of the third FengCheng Rd., WeiYang District, Xi'an City, Shaanxi Province, P.R. China.
Department of Spine Surgery, Honghui Hospital, The Affiliated Hospital of Xi'an Jiaotong University, No. 555 Youyi East Road, Xi'an, Shaanxi 710054, PR China.
Brain Res Bull. 2022 Sep;187:63-74. doi: 10.1016/j.brainresbull.2022.06.014. Epub 2022 Jun 28.
In December 2019, the novel coronavirus disease (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection broke. With the gradual deepening understanding of SARS-CoV-2 and COVID-19, researchers and clinicians noticed that this disease is closely related to the nervous system and has complex effects on the central nervous system (CNS) and peripheral nervous system (PNS). In this review, we summarize the effects and mechanisms of SARS-CoV-2 on the nervous system, including the pathways of invasion, direct and indirect effects, and associated neuropsychiatric diseases, to deepen our knowledge and understanding of the relationship between COVID-19 and the nervous system.
2019 年 12 月，新型冠状病毒病（COVID-19）由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引起。随着对 SARS-CoV-2 和 COVID-19 的逐渐深入了解，研究人员和临床医生注意到这种疾病与神经系统密切相关，对中枢神经系统（CNS）和周围神经系统（PNS）有复杂的影响。在这篇综述中，我们总结了 SARS-CoV-2 对神经系统的影响和机制，包括入侵途径、直接和间接影响以及相关的神经精神疾病，以加深我们对 COVID-19 与神经系统关系的认识和理解。
