Department of Otolaryngology-Head and Neck Surgery, Columbia University, New York, New York, U.S.A.
Department of Medicine, Columbia University, New York, New York, U.S.A.
Laryngoscope. 2021 Mar;131(3):633-638. doi: 10.1002/lary.28859. Epub 2020 Jul 9.
OBJECTIVES/HYPOTHESIS: To analyze the association between early audiometric age-related hearing loss and brain β-amyloid, the pathologic hallmark of Alzheimer's disease (AD).
Cross-sectional analysis of a prospective cohort study.
A cross-sectional analysis was performed on 98 participants in a cohort study of hearing and brain biomarkers of AD. The primary outcome was whole brain β-amyloid standardized uptake value ratio (SUVR) on positron emission tomography (PET). The exposure was hearing, as measured by either pure-tone average or word recognition score in the better ear. Covariates included age, gender, education, cardiovascular disease, and hearing aid use. Linear regression was performed to analyze the association between β-amyloid and hearing, adjusting for potentially confounding covariates.
The mean age ± standard deviation was 64.6 ± 3.5 years. In multivariable regression, adjusting for demographics, education, cardiovascular disease, and hearing aid use, whole brain β-amyloid SUVR increased by 0.029 (95% confidence interval [CI]: 0.003-0.056) for every 10 dB increase in pure-tone average (P = .030). Similarly, whole brain β-amyloid SUVR increased by 0.061 (95% CI: 0.009-0.112) for every 10% increase in word recognition score (P = .012).
Worsening hearing was associated with higher β-amyloid burden, a pathologic hallmark of AD, measured in vivo with PET scans.
3 Laryngoscope, 131:633-638, 2021.
目的/假设：分析早期与年龄相关的听力损失与阿尔茨海默病（AD）病理标志β-淀粉样蛋白之间的关联。
对 AD 听力和大脑生物标志物队列研究的前瞻性队列进行横断面分析。
对 AD 听力和大脑生物标志物队列研究中的 98 名参与者进行了横断面分析。主要结局是正电子发射断层扫描（PET）上的全脑β-淀粉样蛋白标准化摄取值比（SUVR）。听力的暴露是通过纯音平均或较好耳的单词识别得分来衡量的。协变量包括年龄、性别、教育、心血管疾病和助听器的使用。进行线性回归分析，以在调整潜在混杂协变量的情况下分析β-淀粉样蛋白与听力之间的关联。
平均年龄±标准差为 64.6±3.5 岁。在多变量回归中，调整了人口统计学、教育、心血管疾病和助听器的使用后，纯音平均每增加 10dB，全脑β-淀粉样蛋白 SUVR 增加 0.029（95%置信区间[CI]：0.003-0.056）（P=0.030）。同样，全脑β-淀粉样蛋白 SUVR 每增加 10%，单词识别得分增加 0.061（95%CI：0.009-0.112）（P=0.012）。
听力下降与 AD 的病理标志物β-淀粉样蛋白负担增加有关，这是通过 PET 扫描在体内测量的。
3 级喉镜，131：633-638，2021。
