Martínez-Dubarbie Francisco, Lobo David, Rollán-Martínez-Herrera María, López-García Sara, Lage Carmen, Fernández-Matarrubia Marta, Pozueta-Cantudo Ana, García-Martínez María, Corrales-Pardo Andrea, Bravo María, Cobo Ramón, Cabieces-Juncal Daniel, López-Hoyos Marcos, Irure-Ventura Juan, Sánchez-Juan Pascual, Rodríguez-Rodríguez Eloy
Neurology Service, Marqués de Valdecilla University Hospital, Avda. de Valdecilla N25, 39008, Santander, Cantabria, Spain.
Institute for Research Marqués de Valdecilla (IDIVAL), Cantabria, 39011, Santander, Spain.
Neurol Sci. 2024 Apr;45(4):1471-1480. doi: 10.1007/s10072-023-07143-7. Epub 2023 Oct 21.
As Hearing loss and dementia affect people with the same profile, several epidemiological studies have evaluated their relationship. However, the link between age-related hearing loss and Alzheimer's disease is still unclear.
We selected subjects with no history of exposure to loud noises, blasts, head trauma with hearing loss, or sudden sensorineural hearing loss from a cohort intended to study preclinical phases of Alzheimer's disease. Participants are volunteers over 55 years without cognitive impairment. We correlated the results of an objective auditory evaluation with brain amyloid and p-tau181 levels and with the outcomes of a comprehensive neuropsychological assessment.
Fifty-five subjects at different stages of the Alzheimer's disease continuum were evaluated. There were no statistically significant correlations between amyloid-β and p-tau levels and any of the objective auditory measures. A weak but significant correlation was found between amyloid-β values and the Hearing Handicap Inventory for the Elderly. The neuropsychological domains more correlated to hearing loss were executive function and processing speed.
Age-related hearing loss is not linked to any pathological markers of Alzheimer's disease nor to neuropsychological domains typically affected in this disease. The Hearing Handicap Inventory for the Elderly has an important component of subjectivity and further studies are needed to explore its relationship with amyloid-β levels.
由于听力损失和痴呆症影响的人群特征相同，多项流行病学研究对它们之间的关系进行了评估。然而，年龄相关性听力损失与阿尔茨海默病之间的联系仍不明确。
我们从一个旨在研究阿尔茨海默病临床前期阶段的队列中，选取了没有接触过高强度噪音、爆炸、伴有听力损失的头部外伤或突发感音神经性听力损失病史的受试者。参与者为55岁以上无认知障碍的志愿者。我们将客观听觉评估结果与脑淀粉样蛋白和p-tau181水平以及全面神经心理学评估结果进行了关联分析。
对处于阿尔茨海默病连续体不同阶段的55名受试者进行了评估。淀粉样蛋白-β和p-tau水平与任何客观听觉指标之间均无统计学显著相关性。淀粉样蛋白-β值与老年人听力障碍量表之间存在微弱但显著的相关性。与听力损失相关性更强的神经心理学领域是执行功能和处理速度。
年龄相关性听力损失与阿尔茨海默病的任何病理标志物均无关联，也与该疾病中通常受影响的神经心理学领域无关。老年人听力障碍量表具有重要的主观成分，需要进一步研究以探索其与淀粉样蛋白-β水平的关系。
