Ljung B M, Char D, Miller T R, Deschenes J
Department of Pathology, University of California at San Francisco School of Medicine.
Acta Cytol. 1988 Nov-Dec;32(6):840-7.
We retrospectively reviewed the cytology and immunohistochemistry of vitreous cells from 14 patients with benign or malignant intraocular diseases. Nine patients had intraocular lymphoma and five had benign forms of diffuse uveitis. The most useful cytologic criteria for lymphoma included an irregular nuclear outline, a coarse chromatin pattern and prominent nucleoli. In several cases, it was necessary to obtain more than one specimen to establish the diagnosis of lymphoma. When vitreous fluid was mixed with a balanced salt solution prior to processing, a resulting artifact interfered with interpretation of the specimen. A diagnosis of lymphoma was established by cytology in all nine patients; immunohistochemical techniques were less sensitive than was cytology.
我们回顾性分析了14例患有良性或恶性眼内疾病患者的玻璃体细胞的细胞学和免疫组化情况。9例患者患有眼内淋巴瘤，5例患有弥漫性葡萄膜炎的良性形式。诊断淋巴瘤最有用的细胞学标准包括不规则的核轮廓、粗糙的染色质模式和明显的核仁。在一些病例中，有必要获取不止一个标本以确立淋巴瘤的诊断。在处理之前将玻璃体液与平衡盐溶液混合时，产生的假象会干扰对标本的解读。所有9例患者均通过细胞学确诊为淋巴瘤；免疫组化技术的敏感性低于细胞学。
