Kinoshita Yuichi, Takasu Kosho, Adachi Yasuhi, Yuri Takashi, Matsunaga Shiho, Nagumo Sachiko, Shikata Nobuaki
Department of Cytopathology, Kansai Medical University Takii Hospital, Osaka, Japan.
Diagn Cytopathol. 2012 Mar;40(3):210-3. doi: 10.1002/dc.21540. Epub 2010 Nov 15.
Sarcoidosis is an enigmatic multisystem sarcoid disease occurring mainly in the lungs, skin, and eyes. Sarcoidosis of the eyes (intraocular sarcoidosis) has been proposed as one of the causes of uveitis. We carried out a clinicopathological study involving seven patients with intraocular sarcoidosis based on vitreous humor fluid cytology. In the seven patients, the sex ratio was 4:3, and the average age at onset was 65.6-years-old. Vitreous opacity was noted in all patients and snowball-like vitreous opacity in 85.7%. Nerve papilloedema was noted in 42.9%. Diagnostic vitrectomy and adrenocortical hormone therapy were performed in all patients. As a result, the symptoms were improved. Vitreous perfusion fluid cytology revealed multinucleate giant cells in 85.7% and lymphocytes and epithelioid cells in all cases. Cytological diagnosis is not included in the current criteria for sarcoidosis, but its value in the diagnosis of intraocular sarcoidosis was suggested based in present study.
结节病是一种主要发生在肺部、皮肤和眼睛的神秘的多系统结节性疾病。眼部结节病（眼内结节病）被认为是葡萄膜炎的病因之一。我们基于玻璃体液细胞学对7例眼内结节病患者进行了临床病理研究。这7例患者中，男女比例为4:3，平均发病年龄为65.6岁。所有患者均有玻璃体混浊，85.7%的患者有雪球样玻璃体混浊。42.9%的患者有视乳头水肿。所有患者均接受了诊断性玻璃体切除术和肾上腺皮质激素治疗。结果，症状得到改善。玻璃体灌注液细胞学检查显示，85.7%的病例有多核巨细胞，所有病例均有淋巴细胞和上皮样细胞。细胞学诊断并不包括在目前的结节病诊断标准中，但本研究提示了其在眼内结节病诊断中的价值。
