Lenarcic B, Gabrijelcic D, Rozman B, Drobnic-Kosorok M, Turk V
Department of Biochemistry, J. Stefan Institute, Ljubljana.
Biol Chem Hoppe Seyler. 1988 May;369 Suppl:257-61.
Synovial fluid of patients with different inflammatory and metabolic joint diseases contains low-molecular CPIs (stefins and cystatins) and high-molecular CPIs (kininogens). An additional inhibitory fragment with a molecular mass of about 20 kDa, which is a part of the kininogen molecule, has been detected. Cathepsin B and cystatin C were determined by ELISA test in 47 patients with rheumatoid arthritis, seronegative spondylarthritis, osteoarthritis, undifferentiated arthritis and gout. A significantly higher amount of cathepsin B was found in patients with rheumatoid arthritis. The elevation of cathepsin B was accompanied by an increased amount of cystatin C.
患有不同炎症性和代谢性关节疾病的患者的滑液中含有低分子CPI（丝氨酸蛋白酶抑制剂和半胱氨酸蛋白酶抑制剂）和高分子CPI（激肽原）。已检测到一种分子量约为20 kDa的额外抑制性片段，它是激肽原分子的一部分。通过ELISA试验测定了47例类风湿性关节炎、血清阴性脊柱关节炎、骨关节炎、未分化关节炎和痛风患者的组织蛋白酶B和半胱氨酸蛋白酶抑制剂C。类风湿性关节炎患者中发现组织蛋白酶B的含量明显更高。组织蛋白酶B的升高伴随着半胱氨酸蛋白酶抑制剂C含量的增加。
