一切都被照亮了-产气荚膜梭菌β毒素。
Everything Illuminated-Clostridium perfringens β-toxin.
机构信息
Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Harvard Digestive Disease Center, Boston, MA 02115, USA.
出版信息
Cell Host Microbe. 2020 Jul 8;28(1):5-6. doi: 10.1016/j.chom.2020.06.006.
PMID:32645353
Abstract
In this issue of Cell Host & Microbe, Bruggisser et al. show that Clostridium perfringens β-toxin (CPB) binds platelet endothelial cell adhesion molecule-1 (PECAM-1) (also known as CD31) to induce membrane pores. The discovery explains the cell type specificity for CPB and, in large part, the basic pathophysiology of disease.
摘要
在本期《细胞宿主与微生物》中，Bruggisser 等人表明，产气荚膜梭菌β 毒素（CPB）结合血小板内皮细胞黏附分子-1（PECAM-1）（也称为 CD31）以诱导膜孔。这一发现解释了 CPB 的细胞类型特异性，并在很大程度上解释了疾病的基本病理生理学。
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