Nordlind K, Sundström E
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Int Arch Allergy Appl Immunol. 1988;87(3):317-20. doi: 10.1159/000234692.
The influence of adrenaline, noradrenaline, and serotonin (5-hydroxytryptamine) was tested on the proliferative response of peripheral blood T lymphocytes of nickel-allergic subjects to mercuric chloride and nickel sulfate. With addition of the monoamines 1 h after mercuric chloride, there was a marked suppression with all the substances at 10(-4) M, while adrenaline also inhibited down to a concentration of 10(-5) M and serotonin down to 10(-7) M. At 3 days after mercuric chloride, adrenaline inhibited at 10(-4) M and serotonin also down to a concentration of 10(-5) M. With addition at 1 h after nickel sulfate, there was an inhibition by all the monoamines at 10(-4) M, while, in contrast, adrenaline at 10(-6) to 10(-8) M and serotonin at 10(-5) to 10(-6) M gave a stimulation of the response. These findings point at different modulating effects on the proliferative response induced by a polyclonal activator such as mercuric chloride and a monoclonal activator such as nickel sulfate.
研究了肾上腺素、去甲肾上腺素和5-羟色胺（血清素）对镍过敏受试者外周血T淋巴细胞对氯化汞和硫酸镍增殖反应的影响。在加入氯化汞1小时后再添加单胺类物质，所有物质在10⁻⁴ M时均有明显抑制作用，而肾上腺素在浓度降至10⁻⁵ M时仍有抑制作用，血清素在浓度降至10⁻⁷ M时仍有抑制作用。在加入氯化汞3天后，肾上腺素在10⁻⁴ M时有抑制作用，血清素在浓度降至10⁻⁵ M时仍有抑制作用。在加入硫酸镍1小时后添加，所有单胺类物质在10⁻⁴ M时均有抑制作用，而相比之下，肾上腺素在10⁻⁶至10⁻⁸ M以及血清素在10⁻⁵至10⁻⁶ M时则刺激反应。这些发现表明，对由多克隆激活剂（如氯化汞）和单克隆激活剂（如硫酸镍）诱导的增殖反应存在不同的调节作用。
