Ferasin L, Kilkenny E, Ferasin H
Specialist Veterinary Cardiology Consultancy Ltd., Alton, Hampshire, United Kingdom.
Lumbry Park Veterinary Specialists, Alton, Hampshire, United Kingdom.
J Vet Cardiol. 2020 Aug;30:23-31. doi: 10.1016/j.jvc.2020.05.001. Epub 2020 May 18.
To identify the prevalence of systolic anterior motion of the mitral valve (SAM) in apparently healthy cats in the absence of left ventricular hypertrophy (LVH) and examine the relationship between specific cardiac biomarker concentrations and echocardiographic parameters in these individuals.
eighty client-owned cats.
retrospective study; inclusion criteria were the presence of SAM on conscious echocardiography and concurrent measurement of plasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and serum cardiac troponin-I (cTnI). Cats were excluded if they had LVH, left atrial enlargement or systemic disease. The percentages of cats with NT-proBNP and cTnI concentrations above the normal reference range were calculated. The correlation between each biomarker concentration and left ventricular myocardial wall thickness, left atrial size and maximum left ventricular outflow tract velocity was evaluated.
Thirty-four of 80 patients with SAM showed no evidence of cardiac remodelling (LVH or left atrial enlargement). Of these patients, 30 of 34 had elevated NT-proBNP, and cTnI was elevated in 13 of 27 (48.1%) cats where this biomarker was measured in association with the NT-proBNP assay. A positive correlation was observed between concentration of plasma NT-proBNP and maximum left ventricular outflow tract velocity (rs = 0.67, p<0.0001). No significant correlations were found between the concentration of biomarkers and the remaining echocardiographic parameters.
SAM is frequently observed in cats even in the absence of cardiac remodelling, and these individuals often demonstrate elevated plasma NT-proBNP and serum cTnI concentrations. Plasma NT-proBNP elevation is correlated with the severity of the left ventricular outflow obstruction caused by SAM.
确定无左心室肥厚（LVH）的表面健康猫二尖瓣收缩期前向运动（SAM）的患病率，并研究这些个体中特定心脏生物标志物浓度与超声心动图参数之间的关系。
80只客户拥有的猫。
回顾性研究；纳入标准为清醒超声心动图检查存在SAM，并同时测量血浆脑钠肽N末端前体激素（NT-proBNP）和血清心肌肌钙蛋白I（cTnI）。患有LVH、左心房扩大或全身性疾病的猫被排除。计算NT-proBNP和cTnI浓度高于正常参考范围的猫的百分比。评估每种生物标志物浓度与左心室心肌壁厚度、左心房大小和左心室流出道最大速度之间的相关性。
80例SAM患者中有34例无心脏重塑（LVH或左心房扩大）的证据。在这些患者中，34例中有30例NT-proBNP升高，在27例与NT-proBNP检测相关测量该生物标志物的猫中，13例（48.1%）cTnI升高。观察到血浆NT-proBNP浓度与左心室流出道最大速度之间呈正相关（rs = 0.67，p<0.0001）。未发现生物标志物浓度与其余超声心动图参数之间存在显著相关性。
即使在无心脏重塑的情况下，猫中也经常观察到SAM，并且这些个体通常表现出血浆NT-proBNP和血清cTnI浓度升高。血浆NT-proBNP升高与SAM引起的左心室流出道梗阻的严重程度相关。
