Honig Floris, Vermeulen Steven, Zadpoor Amir A, de Boer Jan, Fratila-Apachitei Lidy E
Laboratory for Cell Biology-Inspired Tissue Engineering, MERLN Institute, University of Maastricht, 6229 ET Maastricht, The Netherlands.
BioInterface Science Group, Department of Biomedical Engineering, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
J Funct Biomater. 2020 Jul 7;11(3):47. doi: 10.3390/jfb11030047.
The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between biomaterial properties and the human body are complex. Therefore, a key challenge is to design biomaterials that mimic the in vivo microenvironment. Over millions of years, nature has produced a wide variety of biological materials optimised for distinct functions, ranging from the extracellular matrix (ECM) for structural and biochemical support of cells to the holy lotus with special wettability for self-cleaning effects. Many of these systems found in biology possess unique surface properties recognised to regulate cell behaviour. Integration of such natural surface properties in biomaterials can bring about novel cell responses in vitro and provide greater insights into the processes occurring at the cell-biomaterial interface. Using natural surfaces as templates for bioinspired design can stimulate progress in the field of regenerative medicine, tissue engineering and biomaterials science. This literature review aims to combine the state-of-the-art knowledge in natural and nature-inspired surfaces, with an emphasis on material properties known to affect cell behaviour.
控制功能性生物材料与生物系统之间相互作用的能力对于组织工程和再生医学至关重要。然而，定义生物材料特性与人体之间相互作用的潜在机制很复杂。因此，一个关键挑战是设计出能够模拟体内微环境的生物材料。数百万年来，大自然产生了各种各样针对不同功能进行优化的生物材料，从为细胞提供结构和生化支持的细胞外基质（ECM）到具有特殊润湿性以实现自清洁效果的圣莲。生物学中发现的许多此类系统都具有公认的调节细胞行为的独特表面特性。将这种天然表面特性整合到生物材料中可以在体外引发新的细胞反应，并更深入地了解细胞与生物材料界面处发生的过程。以天然表面为模板进行仿生设计可以推动再生医学、组织工程和生物材料科学领域的进展。这篇文献综述旨在结合天然和仿生表面的最新知识，重点关注已知会影响细胞行为的材料特性。
