Department of Chemistry, Faculty of Valiasr, Tehran Branch, Technical and Vocational University (TVU), Tehran, Iran.
Department of Chemistry, Khodabandeh Branch, Islamic Azad University, Khodabandeh, Iran.
Comb Chem High Throughput Screen. 2021;24(1):88-97. doi: 10.2174/1386207323666200709165325.
Aims & Objective: In this work, the multicomponent reaction of aldehydes, benzoylisothiocyanate and alkyl bromides in the presence of ammonium acetate, sodium cyanide and a catalytic amount of KF/Clinoptilolite nanoparticles (KF/CP NPs) in the water at 100oC was investigated.
In these reactions, thiazole derivatives were produced in good to excellent yields and short time. Also, the antioxidant activity was studied for some newly synthesized compounds using the DPPH radical trapping and reducing of ferric ion experiments and comparing results with the synthetic antioxidants (TBHQ and BHT).
As a result, the compounds 4b showed excellent DPPH radical trapping and reducing the strength of ferric ion. These compounds have biological potential because of the thiazole core. For this reason, the antimicrobial activity of some synthesized compounds was studied by employing the disk diffusion test on Gram-positive bacteria and Gram-negative bacteria.
The results of the disk diffusion test showed that these compounds prevented bacterial growth.
目的与目标：在这项工作中，研究了在 100°C 下，水相中乙酸铵、氰化钠和催化量的 KF/沸石纳米粒子（KF/CP NPs）存在下，醛、苯甲酰异硫氰酸酯和烷基溴的多组分反应。
在这些反应中，噻唑衍生物以良好到优异的产率和短时间生成。此外，还使用 DPPH 自由基捕获和还原铁离子实验研究了一些新合成化合物的抗氧化活性，并将结果与合成抗氧化剂（TBHQ 和 BHT）进行了比较。
结果表明，化合物 4b 对 DPPH 自由基具有优异的捕获和还原铁离子的能力。由于噻唑核心的存在，这些化合物具有生物潜力。因此，通过在革兰氏阳性菌和革兰氏阴性菌上进行圆盘扩散试验研究了一些合成化合物的抗菌活性。
圆盘扩散试验的结果表明，这些化合物阻止了细菌的生长。
