Department of Pharmacy, University of Science and Technology Chittagong, Chattogram, Bangladesh.
Molecular Modeling Drug-Design and Discovery Laboratory, Pharmacology Research Division, BCSIR Laboratories Chattogram, Bangladesh Council of Scientific and Industrial Research, Chattogram, Bangladesh.
Mini Rev Med Chem. 2020;20(19):2036-2051. doi: 10.2174/1389557520666200709175138.
Saurauia roxburghii Wall. is an interesting plant, found growing chiefly along the eastern and south-eastern countries of Asia. The various ethnic groups of these regions use the plant as a medication for relieving a wide spectrum of diseases and conditions, including indigestion, boils, fever, gout, piles, eczema, asthma, ulcers, bronchitis, epilepsy, and hepatitis B. This review aims to appraise the vernacular information, botanical characterization, geographical distribution, traditional uses, phytochemistry, and pharmacological activities of S. roxburghii as well as to conduct a critical analysis on the findings. To understand the therapeutic potential and provide an overall idea about the ethnomedicinal practices, phytochemistry, and pharmacological activities of S. roxburghii, relevant information was collected via a library and electronic search of online journals, books, and reputed databases. Phytochemical examination revealed the presence of alkaloids, glycosides, O-glycosides, flavonoids, carbohydrates, saponins, steroids, reducing sugars, tannins, phlobatannins, and triterpenoids. The sterols were identified as Stigmasterol and beta-Sitosterol. The triterpenes were found to be Ursolic acid, Corosolic acid, Maslinic acid, 24-Hydroxy corosolic acid, 3b,7b,24-trihydroxy-urs-12-en-28-oic acid, Oleanolic acid, beta-Amyrin, cis-3-O-p-Hydroxycinnamoyl ursolic acid, trans-3-O-p- Hydroxycinnamoyl ursolic acid, and 7,24-dihydroxyursolic acid. Several in-vivo and in-vitro tests revealed anti-bacterial, anti-cancer, anti-diabetic, anti-oxidant, and anti-viral activities of the plant leaves. Detailed analysis of the information collected on S. roxburghii suggested some promising leads for future drug development. However, many scientific gaps were found in the study of this and further extensive investigation is needed to fully understand the mechanism of action of the active constituents and exploit its therapeutic promises.
粗毛藤是一种有趣的植物，主要生长在亚洲东部和东南部国家。这些地区的各族群将该植物用作药物，以缓解广泛的疾病和病症，包括消化不良、疖子、发烧、痛风、痔疮、湿疹、哮喘、溃疡、支气管炎、癫痫和乙型肝炎。本综述旨在评估粗毛藤的乡土信息、植物学特征、地理分布、传统用途、植物化学和药理学活性，并对研究结果进行批判性分析。为了了解其治疗潜力并提供有关粗毛藤的民族医学实践、植物化学和药理学活性的总体概念，通过图书馆和在线期刊、书籍和知名数据库的电子搜索收集了相关信息。植物化学研究表明，该植物含有生物碱、糖苷、O-糖苷、类黄酮、碳水化合物、皂苷、类固醇、还原糖、单宁、缩合鞣质、三萜和三萜烯。甾醇鉴定为豆甾醇和β-谷甾醇。三萜烯被鉴定为乌苏酸、科罗索酸、马栗树皮酸、24-羟基乌苏酸、3b、7b、24-三羟基-urs-12-烯-28-酸、齐墩果酸、β-香树脂醇、顺式-3-O-对羟基肉桂酰基乌苏酸、反式-3-O-对羟基肉桂酰基乌苏酸和 7,24-二羟基乌苏酸。几项体内和体外试验表明，该植物叶具有抗细菌、抗癌、抗糖尿病、抗氧化和抗病毒活性。对粗毛藤收集到的信息进行详细分析表明，为未来的药物开发提供了一些有希望的线索。然而，在对该植物的研究中发现了许多科学空白，需要进一步广泛的研究来充分了解活性成分的作用机制并挖掘其治疗潜力。
